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首页> 外文期刊>International journal of legal medicine >Amerindian mitochondrial DNA haplogroups predominate in the population of Argentina: towards a first nationwide forensic mitochondrial DNA sequence database.
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Amerindian mitochondrial DNA haplogroups predominate in the population of Argentina: towards a first nationwide forensic mitochondrial DNA sequence database.

机译：美洲印第安人线粒体DNA单倍体在阿根廷人口中占主导地位：建立第一个全国性的法医线粒体DNA序列数据库。

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摘要

The study presents South American mitochondrial DNA (mtDNA) data from selected north (N = 98), central (N = 193) and south (N = 47) Argentinean populations. Sequence analysis of the complete mtDNA control region (CR, 16024-576) resulted in 288 unique haplotypes ignoring C-insertions around positions 16193, 309, and 573; the additional analysis of coding region single nucleotide polymorphisms enabled a fine classification of the described lineages. The Amerindian haplogroups were most frequent in the north and south representing more than 60% of the sequences. A slightly different situation was observed in central Argentina where the Amerindian haplogroups represented less than 50%, and the European contribution was more relevant. Particular clades of the Amerindian subhaplogroups turned out to be nearly region-specific. A minor contribution of African lineages was observed throughout the country. This comprehensive admixture of worldwide mtDNA lineages and the regional specificity of certain clades in the Argentinean population underscore the necessity of carefully selecting regional samples in order to develop a nationwide mtDNA database for forensic and anthropological purposes. The mtDNA sequencing and analysis were performed under EMPOP guidelines in order to attain high quality for the mtDNA database.
机译：该研究提供了来自选定的阿根廷北部（N = 98），中部（N = 193）和南部（N = 47）种群的南美线粒体DNA（mtDNA）数据。完整的mtDNA控制区（CR，16024-576）的序列分析导致288个独特的单倍型忽略了位置16193、309和573周围的C插入;编码区单核苷酸多态性的额外分析使得能够对所述谱系进行精细分类。美洲印第安人单倍群在北部和南部最为频繁，占序列的60％以上。在阿根廷中部，情况略有不同，美洲印第安人的单倍群只占不到50％，而欧洲的贡献更为相关。美洲印第安人亚单元群的特定进化枝几乎是特定于区域的。在全国各地观察到非洲血统的贡献很小。全世界mtDNA谱系的这种全面混合以及阿根廷人口中某些进化枝的区域特异性，突显了为建立法医学和人类学目的的全国mtDNA数据库而精心选择区域样本的必要性。为了获得高质量的mtDNA数据库，根据EMPOP指南进行了mtDNA测序和分析。

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