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首页> 外文期刊>International journal of medical microbiology: IJMM >N-Acylhomoserine lactone-dependent cell-to-cell communication and social behavior in the genus Serratia
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N-Acylhomoserine lactone-dependent cell-to-cell communication and social behavior in the genus Serratia

机译:沙雷氏菌属的N-酰基高丝氨酸内酯依赖的细胞间通讯和社会行为

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摘要

Members of the genus Serratia are increasingly responsible for nosocomial infections, the treatment of which may be complicated by the appearance of multi-antibiotic-resistant strains. Some but not all Serratia strains and species produce N-acylhomoserine lactones (AHLs), and possess luxR and luxI homologous genes. Phylogenetic comparisons have provided evidence for the lateral transfer of these quorum-sensing systems, and in at least one strain of S. marcescens, transfer via a complex transposon has been experimentally demonstrated. AHL-dependent quorum sensing in Serratia controls population surface migration, biofilm development, the biosynthesis of a carbapenem antibiotic and production of the red pigment, prodigiosin. Serratia also possesses LuxS and produces autoinducer-2 (AI-2) which appears to function as a second quorum-sensing system controlling many of the same phenotypes as the LuxR/AHL systems. (c) 2006 Elsevier GmbH. All rights reserved.
机译:沙雷氏菌属的成员越来越负责医院感染,由于多种抗药性菌株的出现可能会使治疗变得复杂。一些但不是全部的沙雷氏菌菌株和物种产生N-酰基高丝氨酸内酯(AHL),并具有luxR和luxI同源基因。系统发育比较为这些群体感应系统的横向转移提供了证据,并且在至少一种马氏链球菌菌株中,已经通过实验证明了通过复杂转座子的转移。沙雷氏菌中依赖AHL的群体感应控制种群表面迁移,生物膜发育,碳青霉烯抗生素的生物合成以及红色素prodigiosin的产生。沙雷氏菌还具有LuxS并产生自动诱导物2(AI-2),它似乎起着第二群体感应系统的作用,控制着许多与LuxR / AHL系统相同的表型。 (c)2006 Elsevier GmbH。版权所有。

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