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首页> 外文期刊>International journal of medical microbiology: IJMM >Extraintestinal pathogenic Escherichia coli (ExPEC) of human and avian origin belonging to sequence type complex 95 (STC95) portray indistinguishable virulence features
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Extraintestinal pathogenic Escherichia coli (ExPEC) of human and avian origin belonging to sequence type complex 95 (STC95) portray indistinguishable virulence features

机译：属于序列类型复合体95（STC95）的人和禽源性肠外致病性大肠杆菌（ExPEC）表现出难以区分的毒力特征

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摘要

Extraintestinal pathogenic Escherichia coli(ExPEC) strains of certain genetic lineages are frequently implicated in a wide range of diseases in humans and birds. ExPEC strains belonging to the phylogenetic lineage/sequence type complex 95 (STC95) are one such prominent lineage that is commonly isolated from extraintestinal infections such as systemic disease in poultry and urinary tract infections (UTIs), neonatal meningitis and sepsis in humans. Several epidemiological studies have indicated that ST95 strains obtained from such infections may share similar virulence genes and other genomic features. However, data on their ability to establish infections in vivo as deduced from the manifestation of similar virulence phenotypes remain elusive. In the present study, 116 STC95 ExPEC isolates comprising 55 human and 61 avian strains, possessing similar virulence gene patterns, were characterized in vitro using adhesion, invasion, biofilm formation and serum bactericidal assays. Overall, STC95 strains from both groups, namely human and birds, were equally capable of adhering to and invading the two mammalian kidney cell lines. Similarly, these strains were able to form strong biofilms in M63 medium. Furthermore, they were equally resistant to the bactericidal activity of human and avian serum. Our cumulative data reinforce the understanding that ST95 strains from poultry present a potential zoonotic risk and therefore need a One Health strategy for a successfull intervention.
机译：某些遗传谱系的肠外致病性大肠杆菌（ExPEC）菌株通常与人类和鸟类的多种疾病有关。属于系统发育谱系/序列类型复合体95（STC95）的ExPEC菌株就是这样一种突出的谱系，通常从肠外感染中分离出来，例如家禽和泌尿系统感染（UTI）的全身性疾病，新生儿脑膜炎和人类败血症。几项流行病学研究表明，从此类感染获得的ST95菌株可能具有相似的毒力基因和其他基因组特征。但是，关于由类似毒力表型的表现推断出的它们在体内建立感染能力的数据仍然难以捉摸。在本研究中，使用黏附，侵袭，生物膜形成和血清杀菌试验对包含55种人类和61种禽流感毒株的STC95 ExPEC分离株进行了表征，这些毒株具有相似的毒力基因模式。总体而言，来自两组的STC95菌株，即人和鸟类，都同样能够粘附和侵袭两种哺乳动物肾细胞系。同样，这些菌株能够在M63培养基中形成坚固的生物膜。此外，它们同样抗人和禽血清的杀菌活性。我们的累积数据加强了对家禽ST95菌株存在潜在人畜共患病风险的理解，因此需要一种“健康”策略才能成功进行干预。

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