The Significance of Lactate Dehydrogenase Values for Bronchoalveolar Lavage Fluid in Acute Respiratory Distress Syndrome

Noriaki Aoki; Kazui Soma; Toru SekineJ. Robert BeckTakashi Ohwada

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The Significance of Lactate Dehydrogenase Values for Bronchoalveolar Lavage Fluid in Acute Respiratory Distress Syndrome

机译：乳酸脱氢酶值对急性呼吸窘迫综合征支气管肺泡灌洗液的意义

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Lactate dehydrogenase (LDH) in the bronchoalveolar lavage fluid (BALF) of patients with acute respiratory distress syndrome (ARDS) was investigated to evaluate its potential as an indicator of lung injury. Twelve samples from six patients with ARDS and seven samples from five control patients were studied. Bronchoalveolar lavage was performed to measure the percentage of polymorphonuclear leukocytes, albumin, LDH concentration, and its isoenzyme in BALF. In ARDS patients, the percentage of polymorphonuclear leukocytes, albumin, and LDH concentrations in BALF proved to be significantly higher than in control subjects (p < 0.05). The level of BALF-LDH isoenzyme 4 and 5 was higher than that of the other isoenzymes, and both 4 and 5 isoenzymes showed significant negative correlations with the Pao_2/FIo_2 ratio (r = -0.730, and r = -0.759, respectively). The total activity of LDH and isoenzymes in BALF might reflect the extent of pulmonary cellular damage after decreased pulmonary oxygen-ation. Further investigation with a large number of patients will be needed to clarify the clinical usefulness of LDH isoenzyme in BALF.

机译：研究了急性呼吸窘迫综合征（ARDS）患者支气管肺泡灌洗液（BALF）中的乳酸脱氢酶（LDH），以评估其作为肺损伤指标的潜力。研究了来自6名ARDS患者的12份样本和来自5名对照患者的7份样本。进行支气管肺泡灌洗以测量 BALF 中多形核白细胞、白蛋白、LDH 浓度及其同工酶的百分比。在ARDS患者中，BALF中多形核白细胞、白蛋白和LDH浓度的百分比被证明明显高于对照组（p < 0.05）。BALF-LDH同工酶4和5的水平均高于其他同工酶，且4和5同工酶均与Pao_2/FIo_2比呈显著负相关（r=-0.730，r=-0.759）。BALF中LDH和同工酶的总活性可能反映了肺氧合减少后肺细胞损伤的程度。需要对大量患者进行进一步研究，以阐明 LDH 同工酶在 BALF 中的临床实用性。

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《Journal of bronchology: dedicated to the art and science of bronchoscopy and related disciplines》 |2000年第2期|122-126|共5页
作者
Noriaki Aoki; Kazui Soma; Toru SekineJ. Robert BeckTakashi Ohwada;
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作者单位

Information Technology, Baylor College of Medicine, Houston, Texas, U.S.A.;

fDepartment of Emergency and Critical Care;

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原文格式 PDF
正文语种英语
中图分类呼吸系及胸部疾病;
关键词
Acute respiratory distress syndrome; Lactate dehydrogenase; Bronchoalveolar lavage; Bronchoalveolar lavage fluid.;

机译：急性呼吸窘迫综合征;乳酸脱氢酶;支气管肺泡灌洗;支气管肺泡灌洗液。;

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The Significance of Lactate Dehydrogenase Values for Bronchoalveolar Lavage Fluid in Acute Respiratory Distress Syndrome

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