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首页> 外文期刊>Parasitology >The ITin vitroIT anthelmintic activity of the ethanol leaf extracts of ITTerminalia catappaIT L. on ITFasciola giganticaIT
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The ITin vitroIT anthelmintic activity of the ethanol leaf extracts of ITTerminalia catappaIT L. on ITFasciola giganticaIT

机译：ITTerminalia catappaIT L.乙醇叶提取物的IT体外IT驱虫活性ITFasciola giganticaIT

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摘要

At present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPM1-1 640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcGE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000/mu g mL(-1), and at 6 h incubation in 100 and 200 mu g mL(-1). Vacuolization, blebbings and partial disruption on the parasites' tegument were observed by light-microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blobbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may-exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration.
机译：目前，尚无药用植物提取物可用于治疗和控制片形吸虫病。与三氯苯达唑（TCZ）相比，本工作可以为第一项研究提供关于Terminalia catappa L.（TcCE）乙醇提取物与含有TcCE的RPM1-1 640培养基在不同浓度和时间下孵育后对成年片形吸虫的体外杀筋膜化学特性的结论。TcGE处理的吸虫的相对运动性和存活指数值下降速度比TCZ处理的吸虫更快。在400、800和1000 μg mL（-1）孵育3 h以及100和200 μg mL（-1）孵育6 h时，观察到寄生虫的死亡。通过光学显微镜观察寄生虫被毛的真空化、起泡和部分破坏。当通过扫描电子显微镜检查时，TcCE 在寄生虫中引起与在 TCZ 治疗中观察到的相似的被毛改变，但在相对潜伏期具有更大的损伤，包括肿胀、斑点、破裂的水泡、棘的丧失，导致总被毛的侵蚀、损伤和最终破坏。因此，TcCE 可能通过最初引起被毛改变来对巨型镰刀菌发挥其片形杀脂作用。

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