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Quality of life in older adults with aortic stenosis: A narrative review

机译:老年人主动脉瓣狭窄的生活质量:叙事回顾

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Background: Aortic stenosis in older adults can lead to symptoms of breathlessness, dizziness, syncope and angina. While surgical AVR is the optimum treatment, it is not suitable for frail older people who may have other significant comorbidities. TAVI provides a safer alternative. There is evidence that aortic valve replacement reduces mortality and morbidity, but less is known about its effect on quality of life (QoL) in older adults. Aims and objectives: To carry out a narrative review of the existing literature on quality of life (QoL) after surgical aortic valve replacement (AVR) or transcatheter aortic valve replacement (TAVI) with the aim of identifying what is known about QoL pre- and postvalve replacement. Conclusions: There is some evidence that QoL improves after aortic valve replacement, but there are significant gaps in our knowledge. There are no studies that compare QoL after TAVI vs. surgical AVR; thus, we do not know the relative effect of the different procedures on QoL. The literature does not adequately explore why some people have improved QoL after aortic valve replacement and others do not. There appears to be some evidence that the existence of comorbidities may negatively influence QoL after valve replacement, but there is not enough consistent data on comorbidities to explore this further. Study designs are heterogeneous and prevent any meta-analysis of findings. Implications for practice: Decision-making processes regarding the suitability of patients for aortic valve replacement should include an assessment of the potential effects on overall QoL, rather than just relief of cardiac-related symptoms. Consideration of patients' social, emotional and physical needs both before and after valve replacement is essential if health services are serious about improving QoL as well as mortality and morbidity.
机译:背景:老年人的主动脉瓣狭窄可导致呼吸困难,头晕,晕厥和心绞痛症状。虽然外科AVR是最佳治疗方法,但它不适用于可能患有其他重大合并症的体弱的老年人。 TAVI提供​​了更安全的选择。有证据表明,主动脉瓣置换术可降低死亡率和发病率,但对老年人的生活质量(QoL)的影响知之甚少。目的和目标:对外科主动脉瓣置换术(AVR)或经导管主动脉瓣置换术(TAVI)后生活质量(QoL)的现有文献进行叙述性回顾,以了解已知的QoL术前和术后QoL知识。阀后更换。结论:有证据表明主动脉瓣置换后QoL改善,但是我们的知识还存在很大差距。目前尚无研究比较TAVI与手术AVR后的QoL。因此,我们不知道不同程序对QoL的相对影响。文献没有充分探讨为什么有些人在主动脉瓣置换后改善了QoL,而另一些人却没有。似乎有证据表明,合并瓣膜置换术后合并症的存在可能会对QoL产生负面影响,但关于合并症的一致性数据不足,无法进一步探讨。研究设计是异类的,并防止对结果进行任何荟萃分析。实践的意义:关于患者是否适合主动脉瓣置换的决策过程应包括对总体QoL的潜在影响进行评估,而不仅仅是缓解心脏相关症状。如果卫生服务部门认真考虑改善QoL以及死亡率和发病率,那么在更换瓣膜之前和之后必须考虑患者的社会,情感和身体需求。

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