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首页> 外文期刊>International journal of occupational and environmental health : >Benzene percutaneous absorption: dermal exposure relative to other benzene sources.
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Benzene percutaneous absorption: dermal exposure relative to other benzene sources.

机译：苯经皮吸收：相对于其他苯源的皮肤接触。

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摘要

Skin is one of several exposure routes whereby benzene, a widely distributed environmental contaminant that causes leukemia, enters the body, so accurate predictions of its percutaneous absorption are important for risk assessment. Determining benzene's skin-exposure dose and subsequent absorption is difficult because it has a low boiling point and exists as both liquid and vapor. Industrial and environmental benzene is present as a contaminant in other vehicles/solvents, and its percutaneous absorption is in part dependent upon co-solvent volatility. Co-solvents such as benzene in toluene rapidly evaporate from skin, whereas benzene contaminant in water is retained on skin longer due to water's lower volatility. Co-solvents can also affect benzene-skin partition coefficients; thus, permeability coefficients and percentage doses absorbed can vary many-fold. The exposure situation will determine percutaneous absorption, which, if low, can be overwhelmed by benzene intake from the food we eat and the air we breathe.
机译：皮肤是苯（一种广泛分布的引起白血病的环境污染物）进入人体的几种暴露途径之一，因此准确预测其经皮吸收对于风险评估很重要。确定苯的皮肤接触剂量和随后的吸收非常困难，因为苯的沸点低，并且以液体和蒸气形式存在。工业和环境苯在其他媒介物/溶剂中作为污染物存在，其经皮吸收部分取决于助溶剂的挥发性。甲苯中的苯等共溶剂会迅速从皮肤上蒸发，而水中的苯污染物由于水的挥发性较低而在皮肤上的保留时间更长。助溶剂也会影响苯-皮肤的分配系数。因此，渗透系数和吸收的剂量百分比可以变化很多倍。接触情况将决定经皮吸收，如果吸收不足，摄入的食物和呼吸的空气中的苯摄入可能会使该吸收不堪重负。

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