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Paraquat in developing countries.

机译:发展中国家的百草枯。

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摘要

The herbicide paraquat is considered safe by industry and the bulk of regulators worldwide. However, determinants of exposure from 30 years ago persist in developing countries. Little is known about systemic absorption from occupational exposures. The relationships between exposure determinants, levels of external exposure, biomarkers of exposure, and outcomes are not clear. High rates of severe acute poisonings have been documented. In addition, topical injuries occur in as many as 50% of exposed workers. Non-worker populations are also at risk, particularly children. Long-term and delayed health effects include Parkinson's disease, lung effects, and skin cancer. Regulatory agencies have not fully recognized either the inherent toxicity of paraquat or the particular risks derived from exposures in developing countries. Independent risk assessment in the developing-country context and application of the precautionary principle are necessary to prevent adverse effects of dangerous pesticides in susceptible populations.
机译:除草剂百草枯被工业界和全球大多数监管机构认为是安全的。但是,从30年前开始,暴露的决定因素在发展中国家仍然存在。关于因职业暴露引起的全身吸收知之甚少。接触决定因素,外部接触水平,接触生物标志物和结果之间的关系尚不清楚。严重急性中毒的发生率很高。此外,局部受伤发生在多达50%的暴露工人中。非劳动人口,特别是儿童也受到威胁。长期和延迟的健康影响包括帕金森氏病,肺部疾病和皮肤癌。监管机构尚未完全认识到百草枯的内在毒性或发展中国家因暴露而产生的特殊风险。为了防止危险农药对易感人群的不利影响,有必要在发展中国家进行独立的风险评估并采取预防原则。

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