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首页> 外文期刊>International journal of molecular imaging >Comparison of ~111In Leakage from Labeled Endocardial and Epicardial Cells: Impact on Modeling Viability of Cells to Be Transplanted into Myocardium
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Comparison of ~111In Leakage from Labeled Endocardial and Epicardial Cells: Impact on Modeling Viability of Cells to Be Transplanted into Myocardium

机译：标记的心内膜和心外膜细胞〜111In泄漏的比较：对建模的细胞移植到心肌的生存能力的影响

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Introduction. Previously we proposed a cellular imaging technique to determine the surviving fraction of transplanted cells in vivo. Epicardial kinetics using Indium-111 determined the Debris Impulse Response Function (DIRF) and leakage coefficient parameters. Convolution-based modeling which corrected for these signal contributions indicated that ~111In activity was quantitative of cell viability with half-lives within 20 hrs to 37 days. We determine if the 37-day upper limit remains valid for endocardial injections by comparing previous epicardial cell leakage parameter estimates to those for endocardial cells. Methods. Normal canine myocardium was injected (~111In-tropolone) epicardially (9 injections) or endocardially (10 injections). Continuous whole body and SPECT scans for 5 hours were acquired with three weekly follow-up imaging sessions up to 20-26 days. Time-activity curves evaluated each injection type. Results. The epicardial and endocardial kinetics were not significantly different (Epi: 1286 ± 253; Endo: 1567 ± 470 hours P = .62). Conclusion. The original epicardial estimate of leakage kinetics has been validated for use in endocardial injections.
机译：介绍。以前我们提出了一种细胞成像技术来确定体内移植细胞的存活率。使用铟111的心外膜动力学确定了残渣冲激响应函数（DIRF）和泄漏系数参数。基于卷积的模型校正了这些信号贡献，表明〜111In活性定量了细胞存活力，其半衰期为20小时至37天。通过比较先前的心外膜细胞渗​​漏参数估计值与心内膜细胞的参数估计值，我们确定37天上限对于心内膜注射是否仍然有效。方法。正常犬的心肌是通过心外膜注射（约111次注射）或大剂量心内膜内注射（约111次注射）。连续进行了5个小时的全身和SPECT扫描，并连续3周每周进行了长达20-26天的随访成像。时间活动曲线评估了每种注射类型。结果。心外膜和心内膜动力学无明显差异（Epi：1286±253; Endo：1567±470小时，P = .62）。结论。心外膜泄漏动力学的原始心外膜估计值已被验证可用于心内膜注射。

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