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首页> 外文期刊>International journal of molecular medicine >Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
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Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.

机译：在患有或未患有高血压或糖尿病的个体中，遗传变异与心肌梗死的关联。

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Hypertension and diabetes mellitus are important risk factors for myocardial infarction (MI). The purpose of the present study was to identify genetic variants that confer susceptibility to MI in individuals with or without hypertension or diabetes mellitus, thereby contributing to the personalized prevention of MI in such individuals. The study population comprised 5,835 unrelated Japanese individuals, including 1,339 subjects with MI and 4,496 controls. The 150 polymorphisms were selected by genome-wide association studies of MI and ischemic stroke with the use of the GeneChip Human Mapping 500K Array Set. The genotypes for these polymorphisms were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that three different polymorphisms were significantly (P<0.005) associated with the prevalence of MI in individuals with or without hypertension or diabetes mellitus: the C --> T polymorphism of CLEC16A (rs9925481) in individuals without hypertension, the A --> G polymorphism of SEMA3F (rs12632110) in individuals without diabetes mellitus and the A --> G polymorphism of ALOX5 (rs7913948) in individuals without hypertension or diabetes mellitus. No polymorphism was significantly associated with MI in individuals with hypertension, in those with diabetes mellitus, or in those with both conditions. Stratification of subjects based on hypertension or diabetes mellitus may thus be important in order to achieve personalized prevention of MI with the use of genetic information.
机译：高血压和糖尿病是心肌梗塞（MI）的重要危险因素。本研究的目的是鉴定在患有或未患有高血压或糖尿病的个体中赋予MI易感性的遗传变异，从而有助于在此类个体中对MI进行个性化预防。研究人群包括5,835名与日本无关的个体，其中包括1,339名患有MI的受试者和4,496名对照。使用GeneChip Human Mapping 500K Array Set通过MI和缺血性卒中的全基因组关联研究选择了150个多态性。通过将聚合酶链反应和序列特异性寡核苷酸探针与悬浮阵列技术相结合的方法，确定了这些多态性的基因型。卡方检验，对协变量进行调整的多变量logistic回归分析以及逐步的前向选择程序显示，在患有或不患有高血压或糖尿病的个体中，MI的患病率与三种不同的多态性显着相关（P <0.005） ：没有高血压的个体的CLEC16A（rs9925481）的C-> T多态性，没有糖尿病的个体的SEMA3F（rs12632110）的A-> G多态性和ALOX5（rs7913948）的个体A-> G多态性没有高血压或糖尿病。在高血压患者，糖尿病患者或两种情况下，没有多态性与心肌梗死显着相关。因此，基于高血压或糖尿病的受试者分层可能很重要，以便通过使用遗传信息实现对MI的个性化预防。

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