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首页> 外文期刊>International journal of molecular medicine >Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system
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Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system

机译：羟丙基-β-环糊精增强紫杉醇固体脂质纳米粒作为口服给药系统

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摘要

The objective of this study was to evaluate the potential of surface-modified paclitaxel (PTX)-incorporated solid lipid nanoparticles with hydroxypropyl-β-cyclodextrin (smPSH). The smPSH released 89.70±3.99% of its entrapped PTX within 24 h when placed in dissolution medium containing sodium lauryl sulfate. The cellular uptake of PTX from smPSH in Caco-2 cells was 5.3-fold increased compared to a PTX solution based on a Taxol formulation. Moreover, smPSH showed an increased cytotoxicity compared to PTX solution. In addition, AUC (5.43 μg·h/ml) and C max (1.44 μg/ml) of smPSH were higher than those (1.81 μg·h/ml and 0.73 μg/ml) of PTX solution. The drug concentration of smPSH (11.12±4.45 ng/mg of lymph tissue) in lymph nodes was higher than that of the PTX solution (0.89±0.75 ng/mg of lymph tissue), suggesting that more PTX was transported to the lymphatic vessels in the form of smPSH. In conclusion, smPSH have a potential as an alternative delivery system for oral administration of PTX.
机译：这项研究的目的是评估表面修饰的紫杉醇（PTX）结合的固体脂质纳米颗粒与羟丙基-β-环糊精（smPSH）的潜力。将smPSH放入含有十二烷基硫酸钠的溶出介质中后，在24小时内释放了其包裹的PTX的89.70±3.99％。与基于紫杉醇配方的PTX溶液相比，Caco-2细胞中smPSH对PTX的细胞摄取增加了5.3倍。此外，与PTX溶液相比，smPSH显示出更高的细胞毒性。另外，smPSH的AUC（5.43μg·h / ml）和C max（1.44μg/ ml）高于PTX溶液的AUC（1.81μg·h / ml和0.73μg/ ml）。淋巴结中smPSH（11.12±4.45 ng / mg淋巴组织）的药物浓度高于PTX溶液（0.89±0.75 ng / mg淋巴组织）的浓度，表明更多的PTX被转运到淋巴管中。 smPSH的形式。总之，smPSH具有口服PTX替代给药系统的潜力。

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