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首页> 外文期刊>International journal of PIXE >A STUDY ON THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND TRACE ELEMENTS IN GASTRIC MUCOSA
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A STUDY ON THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND TRACE ELEMENTS IN GASTRIC MUCOSA

机译：胃粘膜中幽门螺杆菌与微量元素的关系研究

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摘要

H2 receptor antagonist (H2RA) and proton pump inhibitor(PPI) are often used to treat gastric ulcers, in addition to the zinc-L-carcino-complex which is commonly adopted for such therapies. However, there have been no previous reports detailing the levels and distribution of zinc in human gastric mucosa. The aim of our current study is to clarify the relationship between Helicobacter pylori infection and trace elements such as zinc in gastric mucosa using particle induced X-ray emission (PIXE). Forty gastric ulcer patients were chosen as subjects of this study and divided into two groups. One is a new ulcer patients group(twenty nine cases). And the other, eleven of these patients had been prescribed zinc-L-carcino-complex (polapreZinc), at a dose of 150mg/day for periods ranging from 16 to 20 weeks. The zinc levels in the gastric ulcer group were found to be significantly less than those of the control group and the concentrations of zinc in gastric mucosa were observed to increase following the administration of treatments containing this element.
机译：除了通常用于这种疗法的锌-L-carcino-complex，H2受体拮抗剂（H2RA）和质子泵抑制剂（PPI）通常用于治疗胃溃疡。然而，以前没有报道详细描述人胃粘膜中锌的水平和分布。我们当前研究的目的是通过粒子诱导X射线发射（PIXE）阐明幽门螺杆菌感染与胃黏膜中微量元素（如锌）之间的关系。选择40例胃溃疡患者作为本研究的对象，并分为两组。一个是新的溃疡患者组（29例）。另外，这些患者中有11名接受了L-carcinino-complex（polapreZinc）锌的处方，剂量为150mg /天，持续16至20周。发现胃溃疡组中的锌水平显着低于对照组，并且观察到在施用含这种元素的治疗后胃粘膜中锌的浓度增加。

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