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首页> 外文期刊>International Journal of Pharmaceutics >Organic-inorganic hybrid anion exchange hollow fiber membranes: a novel device for drug delivery.
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Organic-inorganic hybrid anion exchange hollow fiber membranes: a novel device for drug delivery.

机译：有机-无机杂化阴离子交换中空纤维膜：一种新型的药物输送装置。

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摘要

The clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) (such as sodium salicylate (NaSA)) for the treatment of chronic arthritis is limited due to the adverse effects and patient non-compliance. In order to solve these problems, anion exchange hollow fiber membranes (AEHFMs) are proposed for the first time here as potential drug carriers. Brominated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) is used as the starting membrane material. In-situ sol-gel process of gamma-methacryloxypropyl trimethoxysilane (gamma-MPS) in BPPO matrix is operated so as to enhance the membranes' thermal and dimensional stability. The performances of the membranes in controlled release of the drug (NaSA as the model drug) are improved accordingly. Loading and release experiments illustrate that the hybrid AEHFM can bind salicylate (SA) at a high loading efficiency (28.4%), and the retention of the drug on the membrane matrix is significantly prolonged (drug released in 7 days under physiological condition: 51.9%, neglecting the drug bound by protein). Meanwhile, the membrane is biocompatible and can support the adherence, growth, and survival of human cells. Overall, the prepared AEHFM is a promising scaffolding material for drug delivery and tissue engineering.
机译：非甾体抗炎药（NSAID）（例如水杨酸钠（NaSA））在治疗慢性关节炎方面的临床应用受到限制，原因是其不良反应和患者不依从。为了解决这些问题，这里首次提出了阴离子交换中空纤维膜（AEHFMs）作为潜在的药物载体。溴化聚（2,6-二甲基-1,4-苯撑氧）（BPPO）被用作起始膜材料。在BPPO基质中进行γ-甲基丙烯酰氧基丙基三甲氧基硅烷（γ-MPS）的原位溶胶-凝胶工艺，以增强膜的热稳定性和尺寸稳定性。相应地改善了在药物（NaSA作为模型药物）的控释中的膜性能。负载和释放实验表明，杂化AEHFM可以高负载效率（28.4％）结合水杨酸酯（SA），并且药物在膜基质上的保留时间显着延长（药物在生理条件下7天释放：51.9％ ，而忽略了与蛋白质结合的药物）。同时，该膜具有生物相容性，可以支持人类细胞的粘附，生长和存活。总体而言，制备的AEHFM是用于药物输送和组织工程的有前途的支架材料。

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