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首页> 外文期刊>International Journal of Pharmaceutics >Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.
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Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.

机译：潜在的替代润滑剂甘油脂肪酸酯与硬脂酸镁的润滑性能。

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摘要

To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-3.0%, the increase in the pressure transmission ratio that was equal to or greater than that of Mg-St as well as the reduction in the ejection force was observed at a low concentration in both TR-FB and TR-HB, proving that they have excellent lubrication performance. The granules that were lubricated with TR-FB and TR-HB at even low concentration of 0.4% showed a more stable and sufficiently lower ejection force than with Mg-St from the first tablet after the start of compression. When they were mixed for 5-60 min, while the mixture with Mg-St showed a low pressure transmission ratio of 82% and a high ejection force of 500 N in the first tablet even when the mixing time was 60 min, a high pressure transmission ratio and a low ejection force were observed in TR-FB and TR-HB from the first tablet after mixing for 5-60 min, and these were maintained thereafter. As for the disintegration time and the tensile strength, a prolonged disintegration time and a decreased tensile strength, which are disadvantages of Mg-St, were not observed in TR-FB and TR-HB. Based on these results, it was concluded that TR-FB and TR-HB are useful as alternative lubricants to Mg-St.
机译：为了研究甘油脂肪酸酯Poem TR-FB（TR-FB）和Poem TR-HB（TR-HB）作为润滑剂的有用性，在不同浓度下测量了压力传递比，顶出力，崩解时间和拉伸强度。颗粒和片剂的混合时间。当每种润滑剂以0.1-3.0％的比例混合时，在低浓度的TR-FB中都观察到等于或大于Mg-St的压力传递比的增加以及喷射力的减小。和TR-HB，证明它们具有出色的润滑性能。开始压制后，即使是浓度仅为0.4％的低浓度TR-FB和TR-HB润滑的颗粒，其弹力也比Mg-St更高，且稳定性更强。当将它们混合5-60分钟时，即使在混合时间为60分钟时，具有Mg-St的混合物在第一片中仍显示出82％的低压透过率和500 N的高喷射力，混合5-60分钟后，从第一片片剂中观察到TR-FB和TR-HB的透射比和低喷射力，然后将其保持。至于崩解时间和拉伸强度，在TR-FB和TR-HB中未观察到延长的崩解时间和降低的拉伸强度，这是Mg-St的缺点。根据这些结果，可以得出结论，TR-FB和TR-HB可用作Mg-St的替代润滑剂。

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