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首页> 外文期刊>International Journal of Pharmaceutics >Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
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Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.

机译：聚合物纳米颗粒药物递送系统的开发：基于具有糖部分的生物素化聚乙二醇的纳米颗粒评估。

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摘要

Liver specific polymeric nanoparticles were designed and synthesized from biotinylated poly(ethylene glycol) conjugated with lactobionic acid containing a galactose moiety (abbreviated as BEL). Synthesized BEL conjugate was identified by Fourier transform-infrared (FT-IR) and 1H-nuclear magnetic resonance (NMR) spectroscopy. The fluorescence spectroscopy data showed that BEL conjugate was self-assembled in water to form core-shell structure nanoparticles, and the critical association concentration (CAC) value was estimated as 0.028 g/l. From the transmission electron microscope (TEM) observation, the BEL nanoparticles were spherically shaped and ranged in size between 30 and 60 nm. The particle size distribution was measured by photon correlation spectroscopy (PCS), and the result was 41.2+/-11.7 nm. Anti-cancer drug all-trans-retinoic acid (ATRA) was loaded into the BEL nanoparticles for evaluating its efficacy as a drug delivery carrier. The crystallinities of ATRA and ATRA-loaded nanoparticles were examined by X-ray diffraction (XRD) patterns. The ATRA release kinetics from the BEL nanoparticles showed a pseudo zero-order pattern during 1-month period.
机译：从与含半乳糖部分（简称BEL）的乳糖酸共轭的生物素化聚乙二醇设计并合成肝脏特异性聚合物纳米颗粒。通过傅立叶变换红外（FT-IR）和1H核磁共振（NMR）光谱鉴定合成的BEL共轭物。荧光光谱数据表明，BEL缀合物在水中自组装形成核-壳结构纳米粒子，临界缔合浓度（CAC）值估计为0.028 g / l。从透射电子显微镜（TEM）观察，BEL纳米颗粒呈球形，大小在30至60 nm之间。通过光子相关光谱法（PCS）测量粒度分布，结果为41.2 +/- 11.7nm。将抗癌药物全反式维甲酸（ATRA）装入BEL纳米颗粒中，以评估其作为药物递送载体的功效。通过X射线衍射（XRD）模式检查了ATRA和载有ATRA的纳米颗粒的结晶度。 BEL纳米粒子的ATRA释放动力学在1个月内显示出伪零级模式。

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