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首页> 外文期刊>International Journal of Pharmaceutics >Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres.
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Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres.

机译：口服胰岛素载聚（富马酸-共癸二酸）酐微球。

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摘要

The bioadhesive polymer, poly(fumaric-co-sebacic) anhydride, p(FASA), was used to fabricate small diameter insulin microspheres and evaluate their in vivo performance in a type 1 diabetic rat as well as a type 1 diabetic dog model. The process of phase inversion nanoencapsulation was used to fabricate p(FASA) microspheres containing insulin. Using laser diffraction spectrometry, 90% of the microspheres used in the fed double dose rat experiments were found to have a volumetric diameter of 5.9 microm or smaller. In comparison, 90% of the microspheres used in fed single dose rat experiments were found to have a volumetric diameter of 2.6 microm or smaller while the microspheres used in the diabetic dog experiments were found to have a volumetric diameter of 1.2 microm or smaller. Insulin microspheres administered to diabetic rats in the fed double dose experiment produced a relative bioavailability (RB) of 23.3% while insulin microspheres administered to diabetic rats in the fed single dose experiment produced a RB of 5.5+/-1.7%. Insulin microspheres administered to fasted diabetic dogs produced a RB of 5.5+/-3.4%.
机译：生物粘附性聚合物聚（富马酸-共癸二酸）酐p（FASA）用于制备小直径胰岛素微球，并评估它们在1型糖尿病大鼠和1型糖尿病狗模型中的体内性能。相转化纳米封装的过程被用来制造包含胰岛素的p（FASA）微球。使用激光衍射光谱法，发现在喂食双剂量大鼠实验中使用的微球90％的体积直径为5.9微米或更小。相比之下，发现在单剂量饲喂大鼠实验中使用的微球有90％的体积直径为2.6微米或更小，而在糖尿病犬实验中使用的微球的体积直径为1.2微米或更小。在喂养双剂量实验中给予糖尿病大鼠的胰岛素微球产生的相对生物利用度（RB）为23.3％，而在喂养单剂量实验中给予糖尿病大鼠的胰岛素微球产生的RB为5.5 +/- 1.7％。禁食糖尿病犬的胰岛素微球产生的RB为5.5 +/- 3.4％。

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