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首页> 外文期刊>American journal of medical genetics, Part A >Gastroschisis and maternal intake of phytoestrogens
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Gastroschisis and maternal intake of phytoestrogens

机译：胃分裂症和孕妇体内植物雌激素的摄入

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The prevalence of gastroschisis has increased significantly in the past few decades. The strongest risks have been observed for women <25 years old or of low body mass index, and maternal diet also been proposed to be associated with risk. The objective of this study was to evaluate whether the risk of gastroschisis is associated with maternal dietary intake of phytoestrogens. The analysis includes data on mothers of 409 gastroschisis cases and 3,007 controls who delivered their infants from 2005 to 2010 and participated in the National Birth Defects Prevention Study, a multistate, population-based, case-control study. Detailed information was obtained from maternal telephone interviews that included a validated food frequency questionnaire. We conducted logistic regression analyses that included each phytoestrogen in its continuous form (to test for linearity) and quadratic form (to test for non-linearity), adjusted for maternal energy intake, age, BMI, race-ethnicity, and smoking in 1st trimester. Logistic regression analysis indicated that biochanin A, formonoetin, and coumestrol had a significant non-linear association with gastroschisis (P-value <0.05 for quadratic term). Lower intakes were associated with increased risk, with somewhat stronger but relatively modest associations at the lower end of the distribution; for example, the ORs for the 10th versus 50th percentiles ranged from 1.1 to 1.2. Associations were not significant for the other phytoestrogens. This study provides some evidence for association with certain phytoestrogens, after adjusting for covariates. The implications of our findings for clinical practice are uncertain pending other studies examining this association. (c) 2016 Wiley Periodicals, Inc.
机译：在过去的几十年中，胃痉挛的患病率显着增加。对于25岁以下或体重指数较低的女性，观察到最大的风险，并且还建议孕妇饮食与该风险有关。这项研究的目的是评估胃s裂的风险是否与母亲饮食中摄取植物雌激素有关。该分析包括有关2005年至2010年分娩的409例胃gas虫病病例和3,007名对照母亲的数据，他们参加了国家多病种，基于病例的病例对照研究。从孕妇电话访谈中获得了详细信息，其中包括经过验证的食物频率问卷调查。我们进行了逻辑回归分析，包括每种植物雌激素的连续形式（以检验线性）和二次形式（以检验非线性），并根据孕早期的产妇能量摄入，年龄，BMI，种族，种族和吸烟情况进行了调整。 。 Logistic回归分析表明，生物chanin A，formonoetin和coumestrol与胃痉挛之间存在显着的非线性关联（二次项的P值<0.05）。较低的摄入量与增加的风险有关，在分布的较低端具有较强但相对适度的关联。例如，第10个百分位数与第50个百分位数的OR范围为1.1到1.2。关联对其他植物雌激素意义不大。这项研究为校正某些协变量后提供了与某些植物雌激素相关的证据。我们的发现对临床实践的影响尚不确定，尚待其他研究对该关联的研究。 （c）2016年威利期刊有限公司

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