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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Acyclovir suppression to prevent recurrent genital herpes at delivery.
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Acyclovir suppression to prevent recurrent genital herpes at delivery.

机译：抑制阿昔洛韦以防止分娩时生殖器疱疹复发。

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OBJECTIVE: To determine if suppressive acyclovir near term decreased the frequency of clinical recurrences at delivery in women with recurrent genital herpes simplex virus (HSV) infection. METHODS: We conducted a prospective, double-blind, randomized trial in 234 women with recurrent genital herpes. Women with genital infection of any frequency were enrolled. Patients received either suppressive oral acyclovir 400 mg three times daily or an identical placebo after 36 weeks' gestation. Clinical lesions were identified, and HSV cultures were obtained at delivery. The frequencies of clinical and subclinical HSV recurrences at delivery were evaluated. RESULTS: Six percent of patients treated with acyclovir, and 14% of patients treated with placebo had clinical HSV at delivery (p = 0.046). No patients in the acyclovir group had positive HSV cultures, compared with 6% of placebo-treated patients (p = 0.029). There was no significant difference in subclinical HSV shedding in the acyclovir group (0%) compared with the placebo-treated group (3%) (p = 0.102). CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.
机译：目的：确定短期抑制性阿昔洛韦是否能降低生殖器单纯性疱疹病毒（HSV）复发妇女分娩时的临床复发频率。方法：我们对234例复发性生殖器疱疹女性进行了一项前瞻性，双盲，随机试验。登记有任何频率的生殖器感染的妇女。患者在妊娠36周后，每天接受3次400毫克抑制性阿昔洛韦口服治疗，或接受相同的安慰剂。确定了临床病变，并在分娩时获得了HSV培养物。评估分娩时临床和亚临床HSV复发的频率。结果：阿昔洛韦治疗的患者中有6％接受安慰剂治疗，而14％的安慰剂患者则在分娩时具有临床HSV（p = 0.046）。无阿昔洛韦组的患者没有HSV培养阳性，而安慰剂治疗组的患者为6％（p = 0.029）。与安慰剂治疗组（3％）相比，阿昔洛韦组（0％）的亚临床HSV脱落没有显着差异（p = 0.102）。结论：阿昔洛韦抑制治疗显着降低了先前疱疹感染患者的临床生殖器疱疹发生率和分娩时HSV排泄的总体发生率。

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