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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis.
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Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis.

机译：组织学绒毛膜羊膜炎足月患者绒毛膜细胞凋亡。

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OBJECTIVE: The balance between cell survival and cell death (apoptosis) is critical during development and may affect organ function. Apoptosis is accelerated in the presence of infection and inflammation in a variety of organ systems. The objective of this investigation was to determine if apoptosis was increased in the chorion laeve of term patients with and without histologic chorioamnionitis. METHODS: Records of placental pathology were reviewed with respect to the presence/absence of histologic chorioamnionitis. Sections from formalin-fixed, paraffin-embedded fetal membrane rolls were stained using the TUNEL method. The proportion of apoptotic nuclei was calculated in seven high-powered fields/section. Those with and without histologic chorioamnionitis were compared. Data were analyzed using the Mann-Whitney U test, with significance defined as p < 0.05. RESULTS: There was no significant difference in demographic or clinical characteristics between the two groups. The chorion laeve from subjects with histologic chorioamnionitis had significantly more apoptotic nuclei when compared to those without chorioamnionitis (11.2% vs. 5%, p = 0.02). CONCLUSION: Apoptosis is more prevalent in the chorion laeve of fetal membranes with histologic chorioamnionitis. This finding suggests that infection/inflammation may impact cell survival within fetal membranes. The implications of these findings warrant further investigation.
机译：目的：细胞存活与细胞死亡（细胞凋亡）之间的平衡在发育过程中至关重要，并可能影响器官功能。在各种器官系统中存在感染和炎症时，细胞凋亡会加速。这项研究的目的是确定是否有组织学绒毛膜羊膜炎的足月患者绒毛膜凋亡增加。方法：回顾了有关组织学绒毛膜羊膜炎的有无的胎盘病理记录。使用TUNEL方法对福尔马林固定，石蜡包埋的胎膜卷的切片进行染色。在七个高倍视野/切片中计算凋亡核的比例。比较有无组织学绒毛膜羊膜炎者。使用Mann-Whitney U检验分析数据，显着性定义为p <0.05。结果：两组在人口统计学或临床特征上无显着差异。与无绒毛性羊膜炎的患儿相比，患有组织性绒毛性羊膜炎的患儿的绒毛膜凋亡细胞核明显多（11.2％对5％，p = 0.02）。结论：凋亡在组织学绒毛膜羊膜炎的胎膜绒毛膜中更为普遍。这一发现表明，感染/发炎可能会影响胎儿膜内的细胞存活。这些发现的含义值得进一步研究。

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