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Vulvovaginal trichosporonosis.

机译:外阴阴道毛滴虫病。

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OBJECTIVE: Isolation of Trichosporon species from vaginal secretions is a rare event, and no data are available on its pathogenic role. A case series is presented to determine the pathogenic role of Trichosporon species in vulvovaginal infections. METHODS: We performed a retrospective chart review of patients seen in the W.S.U. Vaginitis Clinic in order to identify patients from whom Trichosporon species were isolated. RESULTS: Between 1986 and 2001, a total of 13 patients had a total of 18 positive vaginal cultures for Trichosporon species. All 18 vaginal isolates were T. inkin. In general, positive vaginal cultures were accompanied by low yeast colony counts. Four out of 18 positive T. inkin cultures were obtained from visits by asymptomatic patients. Of the remaining 14 positive T. inkin cultures from patients with symptoms, nine out of 14 cultures had other diagnoses (Candida albicans, six cases; bacterial vaginosis, two cases; Trichomonas, one case). Five positive T. inkin cultures were obtained from visits at which patients had symptoms and no associated diagnosis. In only one of the five episodes could we establish a clear pathogenic role for Trichosporon. In this case the patient was treated with boric acid and had resolution of symptoms and a negative culture at follow-up. In-vitro susceptibility tests revealed that T. inkin was resistant to flucytosine and susceptible to all topical and oral azoles. CONCLUSIONS: T. inkin is occasionally found in vulvovaginal cultures and is usually a non-pathogen. Transient colonization tended to occur in women, usually of African-American origin, with major perturbations in vaginal flora (bacterial vaginosis and trichomoniasis) and increased pH. Pathogenic consequences of Trichosporon colonization appear to be rare.
机译:目的:从阴道分泌物中分离出天花孢子菌是一种罕见的事件,尚无有关其致病作用的数据。介绍了一个病例系列,以确定Trichosporon菌种在外阴阴道感染中的致病作用。方法:我们对W.S.U.阴道炎诊所,以鉴定从中分离出滴虫属的患者。结果:在1986年至2001年之间,共有13位患者的阴道毛孢子菌种共进行了18次阳性阴道培养。所有18个阴道分离物均为T.inkin。通常,阳性阴道培养物伴随着较低的酵母菌落数。从无症状患者的随访中获得了18种阳性T.inkin培养物中的4种。在来自有症状患者的其余14种阳性T.inkin培养物中,有14种培养物中的9种具有其他诊断(白色念珠菌,6例;细菌性阴道病,2例;滴虫,1例)。从患者有症状且无相关诊断的访视中获得了五种阳性的T.inkin培养物。在这五种发作中,只有一种能对Trichosporon发挥明确的致病作用。在这种情况下,患者接受了硼酸治疗,症状得到缓解,随访时培养阴性。体外药敏试验表明,T。inkin对氟胞嘧啶具有抗性,并且对所有局部和口服唑类都很敏感。结论:T. inkin偶尔在外阴阴道培养物中发现,通常是非病原体。短暂定居往往发生在通常是非裔美国人的妇女中,阴道菌群发生严重扰动(细菌性阴道病和滴虫),pH升高。 Trichosporon定植的致病后果似乎很少。

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