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首页> 外文期刊>American journal of medical genetics, Part A >Survival of Texas infants born with trisomies 21, 18, and 13.
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Survival of Texas infants born with trisomies 21, 18, and 13.

机译：出生于21、18和13三体症的德克萨斯州婴儿的生存

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摘要

Trisomies 21, 18, and 13 are the three most common trisomies among infants who survive to 20 weeks gestation or more. Overall information about birth prevalence, natural history, and mortality for all three trisomies is well defined, but information about ethnic-specific rates is limited. Only a few studies have examined mortality rates of trisomies 18 and 13 because so few cases are liveborn and most have very short life spans. This study assessed ethnic-specific population-based survival probabilities among infants for each trisomy. All cases of trisomies 21, 18, and 13 born in Texas between 1999 and 2003 were obtained from the Texas Birth Defects Registry and included 2,260 cases of trisomy 21, 398 cases of trisomy 18, and 213 cases of trisomy 13. Date and cause of death were obtained from the Texas vital statistics records and the National Death Index. Overall, birth prevalence rates (per 10,000 adjusted live births) for the three trisomies were 11.74 (95% CI: 11.25-12.25), 1.34 (95% CI: 1.18-1.52), 0.92 (95% CI: 0.79-1.07), respectively, and are consistent with previously reported rates. There were no differences in survival rates by ethnicity and the median survival for each trisomy was consistent with previous reports. The results of this study provide comprehensive population-based information for survival of infants with trisomies 21, 18, and 13.
机译：21、18和13号三体综合征是存活至20周或更长时间的婴儿中最常见的三个三体性。关于这三个三体症的出生率，自然史和死亡率的总体信息是明确定义的，但是有关特定种族比率的信息却很有限。只有极少数的研究检查了18号和13号三体症的死亡率，因为很少有病例是活产的，大多数病例的寿命很短。这项研究评估了每个三体症在婴儿中基于种族特定人群的生存概率。从德克萨斯出生缺陷登记处获得了1999年至2003年在德克萨斯州出生的所有21、18和13三体性病例，其中包括2260例21三体性，398例18三体性和213例13三体性。死亡数据来自德州生命统计记录和国家死亡指数。总体而言，三个三体症的出生率（每10,000个经调整的活产）分别为11.74（95％CI：11.25-12.25），1.34（95％CI：1.18-1.52），0.92（95％CI：0.79-1.07），分别与先前报告的费率一致。各种族的存活率没有差异，每种三体性的中位存活率与以前的报道一致。这项研究的结果为21、18和13三体性婴儿的生存提供了基于人群的全面信息。

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