...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American journal of medical genetics, Part A >GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection
【24h】

GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection

机译：GenTAC注册报告：遗传性胸主动脉瘤和解剖的个体之间的性别差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous data suggest women are at increased risk of death from aortic dissection. Therefore, we analyzed data from the GenTAC registry, the NIH-sponsored program that collects information about individuals with genetically triggered thoracic aortic aneurysms and cardiovascular conditions. We performed cross-sectional analyses in adults with Marfan syndrome (MFS), familial thoracic aortic aneurysm or dissection (FTAAD), bicuspid aortic valve (BAV) with thoracic aortic aneurysm or dissection, and subjects under 50 years of age with thoracic aortic aneurysm or dissection (TAAD <50 years). Women comprised 32% of 1,449 subjects and were 21% of subjects with BAV, 34% with FTAAD, 22% with TAAD <50 years, and 47% with MFS. Thoracic aortic dissections occurred with equal gender frequency yet women with BAV had more extensive dissections. Aortic size was smaller in women but was similar after controlling for BSA. Age at operation for aortic valve dysfunction, aneurysm or dissection did not differ by gender. Multivariate analysis (adjusting for age, BSA, hypertension, study site, diabetes, and subgroup diagnoses) showed that women had fewer total aortic surgeries (OR=0.65, P<0.01) and were less likely to receive angiotensin converting enzyme inhibitors (ACEi; OR=0.68, P<0.05). As in BAV, other genetically triggered aortic diseases such as FTAAD and TAAD <50 are more common in males. In women, decreased prevalence of aortic operations and less treatment with ACEi may be due to their smaller absolute aortic diameters. Longitudinal studies are needed to determine if women are at higher risk for adverse events.
机译：先前的数据表明，女性因主动脉夹层死亡的风险增加。因此，我们分析了来自美国国立卫生研究院（NIH）资助的GenTAC注册中心的数据，该程序收集有关遗传触发的胸主动脉瘤和心血管疾病患者的信息。我们对患有Marfan综合征（MFS），家族性胸主动脉瘤或夹层（FTAAD），双尖瓣主动脉瓣（BAV）的胸主动脉瘤或夹层以及50岁以下的胸主动脉瘤或成人患者进行了横断面分析解剖（TAAD <50岁）。女性占1,449名受试者的32％，其中BAV受试者占21％，FTAAD受试者占34％，TAAD <50岁的受试者占22％，MFS受试者占47％。性别相同的频率发生胸主动脉夹层，但BAV妇女的夹层更广泛。女性的主动脉大小较小，但控制BSA后相似。主动脉瓣功能不全，动脉瘤或解剖的手术年龄没有性别差异。多变量分析（根据年龄，BSA，高血压，研究地点，糖尿病和亚组诊断进行调整）显示，妇女的总主动脉手术较少（OR = 0.65，P <0.01），接受血管紧张素转换酶抑制剂的可能性较小（ACEi; OR = 0.68，P <0.05）。如在BAV中一样，其他遗传触发的主动脉疾病（如FTAAD和TAAD <50）在男性中更为常见。在女性中，主动脉手术的患病率降低和ACEi治疗较少可能是由于其绝对主动脉直径较小。需要进行纵向研究以确定妇女是否有较高的不良事件风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号