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首页> 外文期刊>American journal of medical genetics, Part C. Seminars in medical genetics >Suicidal behavior: relationship between phenotype and serotonergic genotype.
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Suicidal behavior: relationship between phenotype and serotonergic genotype.

机译：自杀行为：表型与血清素能基因型之间的关系。

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摘要

The basis of suicidal behavior (SB) is complex and multifactorial. Numerous risk factors have been identified. Epidemiological genetics studies (family studies, twin studies, adoption studies) suggest that there is a genetic basis to SB and that this genetic basis is specific and independent from the genetic factors implicated in predisposition to psychiatric disorders associated with SB (bipolar disorder, schizophrenia, alcoholism). Recently, new molecular genetics tools have been designed to identify the genetic factors that predispose certain individuals to disorders of complex etiology. Biological psychiatry studies have suggested that the physiopathology of SB involves dysfunctioning of the serotonin system. The first genetic association studies tested candidate genes encoding proteins involved in serotonin metabolism. The results of these studies suggest that the gene coding for the limiting enzyme in the synthesis of serotonin, tryptophan hydroxylase (TPH), and the gene encoding the serotonin transporter are involved in predisposition to SB. Furthermore, it is likely that these genes interact with each other and with environmental factors (early) and that they have different phenotypic consequences. One of the main aims of studies currently underway is to identify the precise phenotypes associated with genes that predispose to SB or intermediate phenotypes (impulsivity, inability to control anger, etc.).
机译：自杀行为（SB）的依据是复杂和多因素的。已经确定了许多危险因素。流行病学遗传学研究（家庭研究，双生子研究，收养研究）表明，SB有遗传基础，并且该遗传基础是特异性的，并且独立于与SB相关的精神疾病（双相情感障碍，精神分裂症，酗酒）。近来，已经设计了新的分子遗传学工具来鉴定使某些人易患复杂病因的遗传因素。生物精神病学研究表明，SB的生理病理学涉及5-羟色胺系统功能异常。最初的遗传关联研究测试了编码参与血清素代谢蛋白的候选基因。这些研究结果表明，在合成5-羟色胺，色氨酸羟化酶（TPH）中编码限制性酶的基因和编码5-羟色胺转运蛋白的基因与SB的易感性有关。此外，这些基因可能相互影响并与环境因素相互作用（早期），并且它们具有不同的表型后果。目前正在进行的研究的主要目的之一是确定与易患SB或中间表型（冲动，无法控制愤怒等）的基因相关的精确表型。

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