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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Stopping power for particle therapy: The generic library libdEdx and clinically relevant stopping-power ratios for light ions
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Stopping power for particle therapy: The generic library libdEdx and clinically relevant stopping-power ratios for light ions

机译：粒子疗法的制动力：通用库libdEdx和临床上有关轻离子的制动力比

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Purpose: Stopping-power data enter at a number of different places in particle therapy and their uncertainties have a direct impact on the accuracy of the therapy, e.g., in treatment planning. Furthermore, for clinical quality assurance, the particle beam stopping-power ratios (STPR) have to be known accurately for dosimetry. Methods: An open-source computer library called libdEdx (library for energy loss per unit path length, dE/dx, calculations) is developed, providing stopping-power data from data tables and computer programs as well as a stopping-power formula comprising a large list of target materials. Calculations of STPR in the case of spread-out Bragg-peaks (SOBP) are performed with the Monte Carlo transportation code SHIELD-HIT (SHIELD-Heavy Ion Transport) using different ions relevant for particle therapy. Results: For SOBP the water-to-air STPR depends on the residual range and is qualitatively very similar for different ions; however, small quantitative differences exist between the considered ion species. Conclusions: libdEdx allows for a convenient and efficient treatment of stopping powers in numerical applications. It can be applied to estimate the dependence on the accuracy of the stopping power and to provide data for an extended number of target materials. The STPR for SOBP for different ions are found to be qualitatively the same which may allow for an analytical description valid for all ions.
机译：目的：停止功率数据输入到粒子治疗的许多不同位置，其不确定性直接影响治疗的准确性，例如在治疗计划中。此外，为了临床质量保证，对于剂量学，必须准确知道粒子束的停止功率比（STPR）。方法：开发了一个名为libdEdx的开源计算机库（用于单位路径长度能量损耗的库，dE / dx，用于计算），该库提供了来自数据表和计算机程序的停止功率数据以及包括以下内容的停止功率公式：大量目标材料。在散布的布拉格峰（SOBP）情况下，STPR的计算使用与粒子疗法相关的不同离子，使用蒙特卡罗运输代码SHIELD-HIT（SHIELD-重离子迁移）进行。结果：对于SOBP，水-空气STPR取决于残留范围，并且在质量上对于不同的离子非常相似。但是，所考虑的离子种类之间存在小的定量差异。结论：libdEdx允许在数字应用程序中方便有效地处理停止功率。它可用于估计对制动力的准确性的依赖性，并为扩展数量的目标材料提供数据。发现不同离子的SOBP的STPR在质量上是相同的，这可能允许对所有离子有效的分析描述。

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