• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency
【24h】

Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency

机译：在模拟的大规模辐射紧急情况下，采用多生物剂量方法进行分类的实验室间和实验室内比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: The European Union's Seventh Framework Programme-funded project 'Multi-disciplinary biodosimetric tools to manage high scale radiological casualties' (MULTIBIODOSE) has developed a multiparametric approach to radiation biodosimetry, with a particular emphasis on triage of large numbers of potentially exposed individuals following accidental exposures. In November 2012, an emergency exercise took place which tested the capabilities of the MULTIBIODOSE project partners. The exercise described here had a dual purpose: Intercomparison of (i) three biodosimetric assays, and (ii) the capabilities of the seven laboratories, with regards to provision of triage status for suspected radiation exposed individuals. Materials and methods: Three biological dosimetry tools-the dicentric, micronucleus and gamma-H2AX (the phosphorylated form of member X of histone H2A, in response to DNA double-strand breaks) foci assays-were tested, in addition to provision of the triage status results (low exposure: < 1 Gy; medium exposure: 1-2 Gy; high exposure: > 2 Gy) by the MULTIBIODOSE software. The exercise was run in two modes: An initial triage categorisation of samples (based on the first dose estimates for each assay received from each laboratory) followed by collation of the full set of estimated doses (all the results from all modes of each assay carried out by the participating laboratories) calculated using as many modes of operation as possible of the different assays developed during the project. Simulated acute whole body and partial body exposures were included. Results: The results of the initial triage categorisation and the full comparison of assays and methods within and between laboratories are presented here. Conclusions: The data demonstrate that the MULTIBIODOSE approach of applying multiparametric tools to radiation emergencies is valid and effective.
机译：目的：由欧盟第七框架计划资助的项目“用于管理大规模放射伤亡的多学科生物剂量学工具”（MULTIBIODOSE）开发了一种辐射生物剂量学的多参数方法，特别强调了对大量潜在暴露个体进行分类意外接触。 2012年11月，进行了一次紧急演习，测试了MULTIBIODOSE项目合作伙伴的能力。此处描述的练习具有双重目的：（i）三种生物剂量测定法，以及（ii）七个实验室的能力，以为可疑受辐射照射的个人提供分类状况。材料和方法：除提供分类法外，还测试了三种生物剂量测定工具-双着丝粒，微核和γ-H2AX（对DNA双链断裂有反应的组蛋白H2A成员X的磷酸化形式）的焦点测定。状态结果（低曝光：<1 Gy;中曝光：1-2 Gy;高曝光：> 2 Gy）通过MULTIBIODOSE软件进行。该练习以两种模式进行：样本的初始分类分类（基于从每个实验室收到的每种测定的首次剂量估计），然后整理全套估计剂量（每种测定所采用的所有模式的所有结果）使用参与实验的实验室进行计算），并使用项目过程中开发出的不同分析方法的尽可能多的操作模式进行计算。模拟的急性全身和局部身体暴露也包括在内。结果：这里介绍了初始分类分类的结果以及实验室内部和实验室之间的测定方法的全面比较。结论：数据表明，将多参数工具应用于辐射紧急情况的MULTIBIODOSE方法是有效的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号