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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >LET dependence of lethality of carbon ion irradiation to single tobacco cells.
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LET dependence of lethality of carbon ion irradiation to single tobacco cells.

机译：碳离子辐射对单个烟草细胞的致死性的LET依赖性。

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摘要

PURPOSE: To determine the radiation sensitivity and relationship between linear energy transfer (LET) and relative biological effectiveness (RBE) in single plant cells irradiated with heavy ions. MATERIALS AND METHODS: Single cells were isolated from the tobacco BY-2 cell line and irradiated with carbon ions (78.6-309 keV microm(-1)) and gamma-rays (0.2 keV microm(-1)). Two weeks after irradiation, colonies with 16 cells or more derived from the irradiated cells were counted as survivors. The surviving fraction was fitted using the single-hit, multitarget theory. RESULTS: The doses needed to reduce the surviving fraction of the cells to 0.1 (D10) of gamma-rays and carbon ions were 47.2 and 10.5-12.6 Gy, respectively. The RBE based on the D10 peaked at an LET of 247 keV microm(-1). The inactivation cross-section of carbon ions reached a plateau of 11.3 microm2 at an LET of 247 keV microm(-1). CONCLUSIONS: The radiation sensitivity of single tobacco cells was much lower than that of mammalian cells, although the mean number of base pairs per chromosome in the two cell types was similar. The RBE peak based on the D10 of carbon ions in single tobacco cells occurred at a higher LET than it does in other organisms.
机译：目的：确定在重离子辐照下的单个植物细胞中的辐射敏感性以及线性能量转移（LET）和相对生物有效性（RBE）之间的关系。材料与方法：从烟草BY-2细胞系中分离出单细胞，并用碳离子（78.6-309 keV microm（-1））和伽马射线（0.2 keV microm（-1））照射。照射后两周，将来自被照射细胞的具有16个或更多细胞的菌落算作存活者。使用单击多目标理论拟合存活分数。结果：将细胞的存活分数降低至伽玛射线和碳离子的0.1（D10）所需的剂量分别为47.2和10.5-12.6 Gy。基于D10的RBE在247keV microm（-1）的LET处达到峰值。在247 keV microm（-1）的LET下，碳离子的失活截面达到了11.3 microm2的平台。结论：尽管两种细胞类型中每条染色体的平均碱基对数目相似，但单个烟草细胞的辐射敏感性远低于哺乳动物细胞。与其他生物相比，单个烟草细胞中基于碳离子D10的RBE峰的LET更高。

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