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首页> 外文期刊>International Journal of Radiation Oncology, Biology, Physics >Baseline serum testosterone in men treated with androgen deprivation therapy and radiotherapy for localized prostate cancer.
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Baseline serum testosterone in men treated with androgen deprivation therapy and radiotherapy for localized prostate cancer.

机译：男性雄激素剥夺疗法和放射疗法治疗局部前列腺癌的男性基线血清睾丸激素。

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INTRODUCTION: It is believed that men diagnosed with prostate cancer and a low baseline serum testosterone (BST) may have more aggressive disease, and it is frequently recommended they forego testosterone replacement therapy. We used two large Phase III trials involving androgen deprivation therapy and external beam radiation therapy to assess the significance of a BST. METHODS AND MATERIALS: All patients with a BST and complete data (n = 2,478) were included in this analysis and divided into four categories: "Very Low BST" (VLBST) 16.5th percentile and 248 ng/dL but 33rd percentile and 67th percentile (>437 ng/dL; n = 810). Outcomes included overall survival, distant metastasis, biochemical failure, and cause-specific survival. All outcomes were adjusted for the following covariates: treatment arm, BST, age (<70 vs. >/=70), prostate-specific antigen (PSA; <10 vs. 10
机译：简介：据信，被诊断患有前列腺癌和基线血清睾丸激素水平低的男性可能患有更具侵略性的疾病，因此经常建议他们放弃睾丸激素替代治疗。我们使用了两项涉及雄激素剥夺疗法和外部束放射疗法的大型III期试验来评估BST的重要性。方法和材料：所有具有BST和完整数据（n = 2,478）的患者均包括在该分析中，并分为四类：“非常低的BST”（VLBST） 16.5％和 248 ng / dL但 33％和 67％（> 437 ng / dL; n = 810）。结果包括总体生存，远处转移，生化衰竭和特定原因生存。所有结局均针对以下协变量进行了调整：治疗组，BST，年龄（<70 vs。> / = 70），前列腺特异性抗原（PSA; <10 vs. 10

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