Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. In regard to Graham et al. (Int J Radiat Oncol Biol Phys 2010;77(3):648-54.).

Davey P; Smith J; Ennis M

首页> 外文期刊>International Journal of Radiation Oncology, Biology, Physics >Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. In regard to Graham et al. (Int J Radiat Oncol Biol Phys 2010;77(3):648-54.).

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Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. In regard to Graham et al. (Int J Radiat Oncol Biol Phys 2010;77(3):648-54.).

机译：全脑放疗（每日四次使用20 Gy与每天两次两次进行的20 Gy）的脑转移的随机比较。关于格雷厄姆等。（Int J Radiat Oncol Biol Phys 2010; 77（3）：648-54。）。

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Dr. Graham and colleagues are to be congratulated in persevering and completing their randomized study of accelerated whole-brain irradiation for brain metastases (1). The accelerated prescription of 40 Gy in 20 fractions given twice daily gained attention after Vecht et al. (2) reported that this prescription provided a median survival in non-operated patients of 26 weeks. This outcome was far superior to the results previously described in a number of randomized trials of palliative whole-brain irradiation, which typically used daily hypofractionated prescriptions. Our own attempt (3) to reproduce the experience of Vecht et al. failed. However, we are reassured to see the findings of our own randomized study with respect to survival (the same as conventionally hypofractionated radiation) and local control (improved by a factor of ~2) duplicated in the report by Dr. Graham et al

机译：祝贺格雷厄姆博士及其同事坚持并完成他们关于加速全脑辐射治疗脑转移的随机研究（1）。在Vecht等人之后，每天两次给予40 Gy的加速处方20次，引起了关注。（2）报告说，该处方在未手术患者中的中位生存期为26周。这一结果远远优于先前在姑息性全脑照射的许多随机试验中描述的结果，该试验通常使用每日超分割处方。我们自己的尝试（3）重现了Vecht等人的经验。失败了但是，我们可以放心地看到，我们自己的随机研究的结果在Graham等人的报告中重复了关于存活率（与常规的低分割辐射相同）和局部控制（改善了约2倍）的重复

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《International Journal of Radiation Oncology, Biology, Physics》 |2010年第5期|共2页
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Davey P; Smith J; Ennis M;
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1. Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. In regard to Graham et al. (Int J Radiat Oncol Biol Phys 2010;77(3):648-54.). [J] . Davey P, Smith J, Ennis M International Journal of Radiation Oncology, Biology, Physics . 2010,第5期

机译：全脑放疗（每日四次使用20 Gy与每天两次两次进行的20 Gy）的脑转移的随机比较。关于格雷厄姆等。（Int J Radiat Oncol Biol Phys 2010; 77（3）：648-54。）。
2. Radiotherapy in pleural malignant mesothelioma: why not! In regard to Scorsetti et al. (Int J Radiat Oncol Biol Phys 2010;77:942-949); Krayenbuehl et al. (Int J Radiat Oncol Biol Phys 2010;78:628-634). [J] . Russi EG, Numico G, Ricardi U International Journal of Radiation Oncology, Biology, Physics . 2011,第4期

机译：胸膜恶性间皮瘤放疗：为什么不行！关于Scorsetti等。（Int J Radiat Oncol Biol Phys 2010; 77：942-949）; Krayenbuehl等。（Int J Radiat Oncol Biol Phys 2010; 78：628-634）。
3. Low or high fractionation dose b-radiotherapy for pterygium? A randomized clinical trial: In regard to Viani GA et al. (Int J Radiat Oncol Biol Phys 2010;10.1016/j.ijrobp.2010.11.017) [J] . International Journal of Radiation Oncology, Biology, Physics . 2012,第1期

机译：翼状肉的低剂量或高剂量b线放疗？一项随机临床试验：关于Viani GA等。（Int J Radiat Oncol Biol Phys 2010; 10.1016 / j.ijrobp.2010.11.017）
4. Randomized Pilot Study of 20 Gy in 5 Fractions versus 27 Gy in 3 Fractions Radiotherapy for Treating Painful Bone Metastases: A Single Institution Experience [O] . Amr Sakr, Wedad Bassam Hashem, Nadia Ebrahim, 2020

机译：3分数放射治疗疼痛骨转移的3分型放射治疗的5分数与27 Gy的随机试验研究：单一机构经验
5. Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography: still a Pandora's box?: in regard to Devic et al. (Int J Radiat Oncol Biol Phys 2010). [O] . Hatt, Mathieu, Visvikis, Dimitris 2010

机译：关于18F-氟-脱氧-葡萄糖正电子发射断层扫描/计算机断层扫描：仍然是潘多拉魔盒？：就Devic等人而言。（Int J Radiat Oncol Biol Phys 2010）。

Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. In regard to Graham et al. (Int J Radiat Oncol Biol Phys 2010;77(3):648-54.).

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