...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Radiation Oncology, Biology, Physics >Anticipated intraoperative electron beam boost, external beam radiation therapy, and limb-sparing surgical resection for patients with pediatric soft-tissue sarcomas of the extremity: A multicentric pooled analysis of long-term outcomes
【24h】

Anticipated intraoperative electron beam boost, external beam radiation therapy, and limb-sparing surgical resection for patients with pediatric soft-tissue sarcomas of the extremity: A multicentric pooled analysis of long-term outcomes

机译：预期的术中电子束增强，外部束放射治疗和四肢保留小儿肢体软性肉瘤的手术切除：长期预后的多中心汇总分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose To perform a joint analysis of data from 3 contributing centers within the intraoperative electron-beam radiation therapy (IOERT)-Spanish program, to determine the potential of IOERT as an anticipated boost before external beam radiation therapy in the multidisciplinary treatment of pediatric extremity soft-tissue sarcomas. Methods and Materials From June 1993 to May 2013, 62 patients (aged <21 years) with a histologic diagnosis of primary extremity soft-tissue sarcoma with absence of distant metastases, undergoing limb-sparing grossly resected surgery, external beam radiation therapy (median dose 40 Gy) and IOERT (median dose 10 Gy) were considered eligible for this analysis. Results After a median follow-up of 66 months (range, 4-235 months), 10-year local control, disease-free survival, and overall survival was 85%, 76%, and 81%, respectively. In multivariate analysis after adjustment for other covariates, tumor size >5 cm (P=.04) and R1 margin status (P=.04) remained significantly associated with local relapse. In regard to overall survival only margin status (P=.04) retained association on multivariate analysis. Ten patients (16%) reported severe chronic toxicity events (all grade 3). Conclusions An anticipated IOERT boost allowed for external beam radiation therapy dose reduction, with high local control and acceptably low toxicity rates. The combined radiosurgical approach needs to be tested in a prospective trial to confirm these results.
机译：目的对术中电子束放射治疗（IOERT）-西班牙计划中3个贡献中心的数据进行联合分析，以确定IOERT作为小儿四肢软性多学科治疗在外束放射治疗之前的预期增强潜力组织肉瘤。方法和材料从1993年6月至2013年5月，对62例（年龄<21岁）组织学诊断为原发性四肢软组织肉瘤且无远处转移的患者，进行了保留肢体的大体切除手术，外照射治疗（中位剂量） 40 Gy）和IOERT（中值剂量10 Gy）被认为有资格进行此分析。结果在进行了66个月（4-235个月）中位随访，10年局部对照，无病生存期和总生存期分别为85％，76％和81％之后。在对其他协变量进行校正后的多变量分析中，肿瘤大小> 5 cm（P = .04）和R1边缘状态（P = .04）仍与局部复发显着相关。关于整体生存率，多元分析仅保留边缘状态（P = .04）。 10名患者（16％）报告了严重的慢性毒性事件（均为3级）。结论预期的IOERT增强可以降低外部束放射疗法的剂量，并具有较高的局部控制和可接受的低毒性。联合放射外科方法需要在前瞻性试验中进行测试，以证实这些结果。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号