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首页> 外文期刊>International Journal of Radiation Oncology, Biology, Physics >Radiation-free weekend rescued! Continuous accelerated irradiation of 7-days per week is equal to accelerated fractionation with concomitant boost of 7 fractions in 5-days per week: Report on phase 3 clinical trial in head-and-neck cancer patients
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Radiation-free weekend rescued! Continuous accelerated irradiation of 7-days per week is equal to accelerated fractionation with concomitant boost of 7 fractions in 5-days per week: Report on phase 3 clinical trial in head-and-neck cancer patients

机译：周末无辐射获救！每周连续7天的连续加速照射等于加速分级分离，同时每周5天同时增加7个分级照射：头颈癌患者的3期临床试验报告

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Purpose: To report long-term results of randomized trial comparing 2 accelerated fractionations of definitive radiation therapy assessing the need to irradiate during weekend in patients with head and neck squamous cell carcinoma. Methods and Materials: A total of 345 patients with SCC of the oral cavity, larynx, and oro- or hypo-pharynx, stage T2-4N0-1M0, were randomized to receive continuous accelerated irradiation (CAIR: once per day, 7 days per week) or concomitant accelerated boost (CB: once per day, 3 days per week, and twice per day, 2 days per week). Total dose ranged from 66.6-72 Gy, dose per fraction was 1.8 Gy, number of fractions ranged from 37-40 fractions, and overall treatment time ranged from 37-40 days. Results: No differences for all trial end-points were noted. At 5 and 10 years, the actuarial rates of local-regional control were 63% and 60% for CAIR vs 65% and 60% for CB, and the corresponding overall survival were 40% and 25% vs 44% and 25%, respectively. Confluent mucositis was the main acute toxicity, with an incidence of 89% in CAIR and 86% in CB patients. The 5-year rate of grade 3-4 late radiation morbidity was 6% for both regimens. Conclusions: Results of this trial indicate that the effects of accelerated fractionation can be achieve by delivering twice-per-day irradiation on weekday(s). This trial has also confirmed that an accelerated, 6-weeks schedule is a reasonable option for patients with intermediate-stage head-and-neck squamous cell carcinoma because of the associated high cure rate and minimal severe late toxicity. ? 2013 Elsevier Inc. All rights reserved.
机译：目的：报告一项随机试验的长期结果，比较确定性放射治疗的两种加速分级方法，评估头颈部鳞状细胞癌患者周末是否需要放疗。方法和材料：总共345例口腔，喉和口咽或下咽的SCC患者（T2-4N0-1M0期）随机接受连续加速照射（CAIR：每天一次，每次7天每周一次）或伴随的加速提升（CB：每天一次，每周3天，每天两次，每周2天）。总剂量为66.6-72 Gy，每级分剂量为1.8 Gy，级分数为37-40级，总治疗时间为37-40天。结果：没有注意到所有试验终点的差异。在5年和10年时，CAIR的局部控制精算率分别为63％和60％，而CB为65％和60％，相应的总生存率分别为40％和25％对44％和25％ 。融合粘膜炎是主要的急性毒性，在CAIR中的发生率为89％，在CB患者中的发生率为86％。两种方案的3-4级晚期放射病发病率的5年率为6％。结论：该试验的结果表明，通过在工作日每天进行两次照射可以达到加速分馏的效果。该试验还证实，对于中晚期头颈部鳞状细胞癌患者，由于具有较高的治愈率和最小的严重晚期毒性，因此加速的6周时间表是合理的选择。 ？ 2013 Elsevier Inc.保留所有权利。

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