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首页> 外文期刊>International journal of sport nutrition >Intestinal permeability in runners in the 1996 Chicago marathon.
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Intestinal permeability in runners in the 1996 Chicago marathon.

机译：1996年芝加哥马拉松比赛中运动员的肠道通透性。

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Abdominal cramping, nausea, diarrhea, and GI bleeding are often reported in long-distance runners. This study set out to determine the effects of prolonged (2-4 hrs) exercise and NSAID ingestion on gastric and intestinal permeability during the first 5 hrs following the 1996 Chicago Marathon. Thirty-four healthy volunteers (20 M, 14 F; ages 30-50) completed the race and ingested the test solution (5 g sucrose, 5 g lactulose, 2 g rhamnose, in 40 ml water) within 10-15 min. The urinary excretion ratio of lactulose/rhamnose was used to assess small intestine permeability; sucrose excretion was used to evaluate gastric impairment. There were no significant differences for mean training mileage, postrace rectal temperature, and percent dehydration between runners who ingested NSAIDs and those who did not. In all, 75% of subjects reported aspirin or ibuprofen ingestion before or during the race. Runners who ingested ibuprofen had significant elevations in urinary lactulose excretion and lactulose/rhamnose ratio, whereas those who ingested aspirin or who did not ingest either NSAID had no significant differences in urinary excretion of lactulose, rhamnose, sucrose, or lactulose/rhamnose ratio compared to resting controls. Thirteen of the 26 NSAID users and 4 of the 8 non-users reported GI symptoms. It is concluded that (a) ibuprofen but not aspirin ingestion during prolonged exercise may increase gastrointestinal permeability and lead to GI symptoms, and (b) prolonged exercise alone can produce GI symptoms.
机译：在长跑运动员中经常有腹部绞痛，恶心，腹泻和胃肠道出血的报道。这项研究的目的是确定在1996年芝加哥马拉松赛后的最初5个小时内，长时间（2-4小时）运动和NSAID摄入对胃和肠通透性的影响。三十四名健康志愿者（20 M，14 F; 30-50岁）完成了比赛，并在10-15分钟内摄入了测试溶液（5 g蔗糖，5 g乳果糖，2 g鼠李糖，溶于40 ml水中）。乳果糖/鼠李糖的尿排泄率用于评估小肠通透性。蔗糖排泄用于评估胃功能障碍。摄入NSAID的跑步者与未摄入NSAID的跑步者之间的平均训练里程，赛后直肠温度和脱水百分比没有显着差异。总共有75％的受试者在比赛前或比赛中报告了阿司匹林或布洛芬的摄入。摄入布洛芬的跑步者的尿中乳果糖排泄量和乳果糖/鼠李糖比显着升高，而摄入阿司匹林或未摄入任何NSAID的跑步者的尿中乳果糖，鼠李糖，蔗糖或乳果糖/鼠李糖比与尿素的排泄率无显着差异。休息控制。 26位NSAID用户中有13位和8位非用户中有4位报告了胃肠道症状。结论是：（a）长时间运动期间摄入布洛芬但不摄入阿司匹林可增加胃肠道通透性并导致GI症状;（b）长时间运动可单独产生GI症状。

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