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首页> 外文期刊>Advances in neonatal care: official journal of the National Association of Neonatal Nurses >Probiotic Guideline for Necrotizing Enterocolitis Prevention in Very Low-Birth-Weight Neonates
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Probiotic Guideline for Necrotizing Enterocolitis Prevention in Very Low-Birth-Weight Neonates

机译：极低出生体重新生儿坏死性小肠结肠炎的预防性益生菌指南

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摘要

Necrotizing enterocolitis (NEC) is a gastrointestinal emergency that leads to inflammation and intestinal necrosis. Although probiotics can decrease the incidence of NEC, consistent recommendations for probiotic administration to very low-birth-weight (VLBW) neonates are lacking. Here, the best available evidence is reviewed and a practice guideline for probiotic administrations to VLBW neonates is described. A systematic review was conducted using MEDLINE and EMBASE, and the strength of evidence was classified using the Centre for Evidence-Based Medicine classification schema. Probiotics for VLBW neonates may decrease the incidence of NEC. Providers may choose to give probiotics to VLBW neonates at risk of acquiring NEC in facilities with a high NEC incidence. Clinicians must monitor infants for possible adverse effects. Contraindications for probiotic use include extremely low birth weight, clinical instability, abnormal abdominal examination, the presence of congenital abnormalities, post-NEC, stage III asphyxia, and umbilical catheters.
机译：坏死性小肠结肠炎（NEC）是胃肠道紧急情况，会导致炎症和肠道坏死。尽管益生菌可以降低NEC的发生率，但仍缺乏针对极低出生体重（VLBW）新生儿益生菌给药的一致建议。在此，将对最佳的可用证据进行综述，并介绍对VLBW新生儿进行益生菌给药的实践指南。使用MEDLINE和EMBASE进行了系统的审查，并使用了循证医学中心分类方案对证据的强度进行了分类。 VLBW新生儿的益生菌可以降低NEC的发生率。提供者可以选择在高NEC发生率的设施中为有患NEC风险的VLBW新生儿提供益生菌。临床医生必须监视婴儿可能的不良反应。使用益生菌的禁忌症包括极低的出生体重，临床不稳定，腹部检查异常，先天性异常，NEC后，III期窒息和脐带导管。

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