Local structure is critical for superoxide dismutase activity in copper complexes: Relationship between EPR parameters, structure and activity in some sterically hindered copper(II) bis(hydrazono-triazine) complexes

Goodman BA.; Palivan CG.; Palivan H.; Tomas S.

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Local structure is critical for superoxide dismutase activity in copper complexes: Relationship between EPR parameters, structure and activity in some sterically hindered copper(II) bis(hydrazono-triazine) complexes

机译：局部结构对于铜配合物中的超氧化物歧化酶活性至关重要：某些空间受阻的铜（II）双（肼基三嗪）配合物的EPR参数，结构和活性之间的关系

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Electron paramagnetic resonance (EPR) spectrometry and molecular mechanics force field calculations have been performed on some sterically hindered copper(II) complexes with hydrazonotriazine ligands, in order to gain further insight into the relationship between their bonding, structures and biological activity. As was the case with Cu(II) bis(hydrazono-triazine) complexes studied previously, the most stable configuration for all of the complexes involves coordination of two nitrogen and two oxygen atoms (2N2O) in a distorted tetragonal arrangement. With the present complexes, however, the superoxide radical scavenging activities were very low, a result which may be explained by their inability to form a (nearly) square planar structure, which facilitates the copper redox cycling during superoxide dismutation. [References: 28]

机译：电子顺磁共振（EPR）光谱和分子力学力场计算已对某些具有肼基三嗪配体的位阻铜（II）配合物进行了研究，以进一步了解其键合，结构与生物学活性之间的关系。与以前研究的Cu（II）双（肼基三嗪）配合物一样，所有配合物的最稳定构型都涉及两个氮原子和两个氧原子（2N2O）的四边形扭曲配位。然而，对于本发明的配合物，超氧化物自由基的清除活性非常低，其结果可以解释为它们不能形成（几乎）正方形的平面结构，这有助于铜在超氧化物歧化过程中的氧化还原循环。 [参考：28]

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《Applied Magnetic Resonance》 |2003年第1期|共16页
作者
Goodman BA.; Palivan CG.; Palivan H.; Tomas S.;
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正文语种 eng
中图分类电磁学、电动力学;
关键词
Paramagnetic-resonance spectroscopy; Aided-design cad; Coordination environment; Esr; Spectra; Redox;

机译：顺磁共振光谱法;辅助设计cad;配位环境;Esr;光谱;氧化还原;

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1. Local structure is critical for superoxide dismutase activity in copper complexes: Relationship between EPR parameters, structure and activity in some sterically hindered copper(II) bis(hydrazono-triazine) complexes [J] . Goodman BA., Palivan CG., Palivan H., Applied Magnetic Resonance . 2003,第1期

机译：局部结构对于铜配合物中的超氧化物歧化酶活性至关重要：某些空间受阻的铜（II）双（肼基三嗪）配合物的EPR参数，结构和活性之间的关系
2. Synthesis, crystal structures, and superoxide dismutase activity of two isostructural copper(II)-zinc(II) complexes derived from A^,A^-bis(4-methoxysalicylidene) cy clohexane-1,2-diamine [J] . ZHONG-LU YOU, LI-LI NI, PENG HOU Journal of Coordination Chemistry . 2010,第3期

机译：两种衍生自A ^，A ^-双（4-甲氧基水杨基）环己烷-1,2-二胺的同构铜（II）-锌（II）配合物的合成，晶体结构和超氧化物歧化酶活性
3. Synthesis, crystal structures, and superoxide dismutase activity of two isostructural copper(II)-zinc(II) complexes derived from N,Nâ²-bis(4-methoxysalicylidene)cyclohexane-1,2-diamine [J] . Zhong-Lu You Journal of Coordination Chemistry . 2010,第3期

机译：合成，晶体结构和超氧化物歧化酶活性的两个同构铜（II）-锌（II）配合物衍生自N，Nβ-双（4-甲氧基水杨基）环己烷-1，2-二胺
4. Chitosan- Copper(II) , Zinc(II) and Ferric(II) Complexes as Antimicrobial Agent: Synthesis, Characterization and Structure- Activity Study [C] . Xiaohui Wang, Yumin Du, Fei Huang Polymeric Materials: Science Engineering Symposia . 2005

机译：壳聚糖 - 铜（II），锌（II）和铁（II）复合物作为抗微生物剂：合成，表征和结构 - 活性研究
5. Relationship between ligand structure and reactivity for copper(II) complex mediated hydrolysis of phosphate diesters, carboxylic esters, and amides. Part~I. Hydrolysis of phosphate diesters promoted by copper(II) complexes. Part~II. Hydrolysis of carboxylic esters and amides catalyzed by copper(II) complexes. [D] . Jubian, Vrej. 1991

机译：铜（II）配合物介导的磷酸二酯，羧酸酯和酰胺水解的配体结构与反应性之间的关系。第一部分铜（II）配合物促进的磷酸二酯的水解。第二部分铜（II）配合物催化的羧酸酯和酰胺的水解。
6. Synthesis characterization and potent superoxide dismutase like activity of novel bis(pyrazole) – 22′-bipyridyl mixed ligand copper(II) complexes [O] . Andrei S. Potapov, Evgenia A. Nudnova, Galina A. Domina, -1

机译：新型双（吡唑） - 22-双吡啶混合配体铜（II）配合物的合成表征和有效超氧化物歧化酶等活性
7. Bis(m-oxo)dicopper(III) Complexes of a Homologous Series of Simple Peralkylated 1, 2-Diamines: Steric Modulation of Structure, Stability, and Reactivity [O] . -1

机译：双（m-oxo）双泊孔（III）络合物的单身系列简单脱圆形的1,2-二胺：结构，稳定性和反应性的空间调节
8. CRYSTAL STRUCTURES OF NICKEL AND COPPER COMPOUNDS PART I. TWO BIS COMPLEXES OF 2.2’-IMINOBIS (ACETAMIDOXIME) PART II REGULAR OCTAHEDRAL COPPER (II) COMPLEXES [R] . DAVID LAWRENCE CULLEN 1969

机译：镍和铜化合物的晶体结构第一部分2.2'-亚氨基（乙酰氨基）第二部分正二甲基铜（Ⅱ）配合物的两个双配合物

Local structure is critical for superoxide dismutase activity in copper complexes: Relationship between EPR parameters, structure and activity in some sterically hindered copper(II) bis(hydrazono-triazine) complexes

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