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首页> 外文期刊>International Journal of Neuroscience >Vascular endothelial growth factor in tuberculous meningitis
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Vascular endothelial growth factor in tuberculous meningitis

机译：结核性脑膜炎中的血管内皮生长因子

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Vascular endothelial growth factor (VEGF) is linked to brain edema and infarction, but there is paucity of studies correlating VEGF level with magnetic resonance imaging (MRI) changes in tuberculous meningitis (TBM). The aim of this study was to measure serum VEGF level in TBM and correlate it with clinical, laboratory, and MRI findings. Forty patients with TBM underwent cranial evaluation, cranial MRI, and MR angiography (MRA). Presence of exudates, hydrocephalous, infarction, tuberculoma, and MRA abnormalities was noted. Serum VEGF level was measured by enzyme-linked immunosorbent assay and compared in patients and controls. The VEGF level was also correlated with clinical, MRI, and MRA findings. The median age of the patients was 26.5 years. There was a trend towards higher serum VEGF level in TBM patients (100.7 ± 110.6 pg/ml) compared to the controls (60.6 ± 20.3 pg/ml). There was also a trend towards higher VEGF level in patients with shorter duration of illness (127.5 ± 152.4 pg/ml vs 76.5 ± 40.9 pg/ml), MRI evidence of infarction (131.4 ± 150.7 pg/ml vs 73.0 ± 41.4 pg/ml), and paradoxical response (122.3 ± 157.6 pg/ml vs 88.8 ± 50.8 pg/ml). Five patients died, and death was not related to VEGF level. It can be concluded that serum VEGF level in TBM patients is insignificantly higher in those with shorter duration of illness and infarction.
机译：血管内皮生长因子（VEGF）与脑水肿和梗塞有关，但尚无相关研究将VEGF水平与结核性脑膜炎（TBM）的磁共振成像（MRI）变化相关。这项研究的目的是测量TBM中的血清VEGF水平，并将其与临床，实验室和MRI发现相关联。 40例TBM患者接受了颅骨评估，颅骨MRI和MR血管造影（MRA）。注意到存在渗出液，脑积水，梗塞，结核和MRA异常。通过酶联免疫吸附测定法测量血清VEGF水平，并在患者和对照中进行比较。 VEGF水平还与临床，MRI和MRA发现相关。患者的中位年龄为26.5岁。与对照组（60.6±20.3 pg / ml）相比，TBM患者的血清VEGF水平有升高的趋势（100.7±110.6 pg / ml）。病程较短的患者（127.5±152.4 pg / ml与76.5±40.9 pg / ml）的VEGF水平也有升高的趋势，MRI证实有梗塞（131.4±150.7 pg / ml与73.0±41.4 pg / ml ）和反常的响应（122.3±157.6 pg / ml对88.8±50.8 pg / ml）。 5例患者死亡，且死亡与VEGF水平无关。可以得出结论，在疾病和梗塞持续时间较短的患者中，TBM患者的血清VEGF水平微不足道。

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