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首页> 外文期刊>International Journal of Neuroscience >The effect of bupivacaine on compound action potential parameters of sciatic nerve fibers.
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The effect of bupivacaine on compound action potential parameters of sciatic nerve fibers.

机译：布比卡因对坐骨神经纤维复合动作电位参数的影响。

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摘要

The aim of this study was to document the effects of the local anesthetic agent bupivacaine on individual fibers of peripheral nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated frog sciatic nerves treated with bupivacaine for seven individual concentration levels. Numerical and fast Fourier transform (FFT) analysis were performed on these recordings. The areas, latency periods, maximum and minimum derivatives, and power spectrums of the CAPs were computed. The results show that the area and the absolute values of maximum and minimum derivatives decrease linearly as bupivacaine concentration increases. The power spectrum of the CAPs, which resides in the 0-1000 Hz interval, initially shifts to higher frequencies then returns to lower frequency region again with increasing bupivacaine concentration. Due to this result, it is thought that bupivacaine inhibits nerve fibers in a dose-dependent manner. It primarily affects the fibers having the least myelin sheets (motor fibers), then it begins to depress the fast conducting (neurosensorial) fibers as the bupivacaine concentration increases, and finally blocks the unmyelinated C-fibers.
机译：这项研究的目的是证明局部麻醉药布比卡因对周围神经的单个纤维的作用。为了达到这个目的，从布比卡因治疗七个单独浓度水平的离体蛙坐骨神经中记录了复合动作电位（CAPs）。在这些记录上进行了数值和快速傅里叶变换（FFT）分析。计算了CAP的面积，等待时间，最大和最小导数以及功率谱。结果表明，随着布比卡因浓度的增加，最大和最小导数的面积和绝对值线性减小。 CAP的功率谱位于0-1000 Hz区间，最初会随着布比卡因浓度的增加而移至较高的频率，然后再次返回至较低的频率区域。由于该结果，认为布比卡因以剂量依赖性方式抑制神经纤维。它主要影响髓鞘层最少的纤维（运动纤维），然后随着布比卡因浓度的增加，开始抑制速导（神经感觉）纤维，最后阻塞未髓鞘的C纤维。

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