Application of diffusion-ordered spectroscopy for the analysis of cancer related biological samples

G. I. Ivanova; E. J. Cabrita; R. O Connor; A. J. Eustace; D. F. Brougham

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Application of diffusion-ordered spectroscopy for the analysis of cancer related biological samples

机译：扩散有序光谱学在癌症相关生物样品分析中的应用

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A preliminary application of diffusion-ordered spectroscopy (DOSY) for separation, identification andcharacterisation of metabolites of human lung carcinoma cell extracts, exhibiting different levels of multi-drugresistance (MDR) is reported. The results show the presence of at least three lipid components of different sizes in thelipophilic extracts which can not be identified by one- and two-dimensional NMR techniques. A number of metabolitesin the hydrophilic extracts of human lung carcinoma cell lines are successfully separated by different diffusivities. Theappearance in the DOSY spectra of different metabolites with the same diffusion coefficient is consistent with thembeing chemically bound together.

机译：据报道，扩散有序光谱法（DOSY）在人类肺癌细胞提取物的代谢物的分离，鉴定和表征中具有初步的应用，表现出不同水平的多药耐药性（MDR）。结果显示在亲脂性提取物中存在至少三种不同大小的脂质组分，这不能通过一维和二维NMR技术鉴定。人肺癌细胞系亲水性提取物中的许多代谢物可通过不同的扩散性成功分离。具有相同扩散系数的不同代谢物在DOSY光谱中的出现与其化学键合一致。

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来源
《Bulgarian chemical communications: Journal of the Chemical Institutes of the Bulgarian Academy of Sciences and of the Bulgarian Chemical Society》 |2008年第4期|共5页
作者
G. I. Ivanova; E. J. Cabrita; R. O Connor; A. J. Eustace; D. F. Brougham;
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正文语种 eng
中图分类化学;
关键词
cells; composition; NMR; adiffusion; DOSY;

机译：细胞;组成;NMR;扩散;DOSY;

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1. Application of diffusion-ordered spectroscopy for the analysis of cancer related biological samples [J] . G. I. Ivanova, E. J. Cabrita, R. O Connor, Bulgarian chemical communications: Journal of the Chemical Institutes of the Bulgarian Academy of Sciences and of the Bulgarian Chemical Society . 2008,第4期

机译：扩散有序光谱学在癌症相关生物样品分析中的应用
2. Li-6 Diffusion-Ordered NMR Spectroscopy (DOSY) and Applications to Organometallic Complexes [J] . Kagan G, Li WB, Hopson R, Organic letters . 2010,第3期

机译：Li-6扩散有序NMR光谱学（DOSY）及其在有机金属配合物中的应用
3. Feasibility study for the rapid screening of target molecules using translational diffusion coefficients: Diffusion-ordered NMR spectroscopy of biological toxins [J] . Henderson T.J. Analytical and bioanalytical chemistry . 2010,第4期

机译：使用翻译扩散系数快速筛选目标分子的可行性研究：生物毒素的扩散排序NMR光谱
4. A method for joint sparse sampling of time and gradient domains in diffusion-ordered NMR spectroscopy [C] . Urbanczyk Mateusz, Kazimierczuk Krzysztof Signal Processing Symposium . 2013

机译：扩散有序NMR光谱中时域和梯度域的联合稀疏采样方法
5. Super-resolution Harmonic Inversion of Time Signals using Filter Diagonalization Method with Applications to NMR Diffusion-Ordered Spectroscopy and Fourier Transform Mass Spectrometry. [D] . Martini, Beau Rocky. 2014

机译：使用滤波器对角化方法对时间信号进行超高分辨率谐波反演，并应用于NMR扩散有序光谱学和傅里叶变换质谱。
6. Analysis of Polycyclic Aromatic Hydrocarbon (PAH) Mixtures Using Diffusion-Ordered NMR Spectroscopy and Adsorption by Powdered Activated Carbon and Biochar [O] . Dong An, Chengchen Guo, Yanan Chen 2018

机译：扩散有序NMR光谱和粉末状活性炭和生物炭的吸附分析多环芳烃（PAH）混合物
7. Application of 6Li diffusion-ordered NMR spectroscopy (DOSY) to confirming the solution structure of n-butyllithium [O] . Paul G. Williard, Weibin Li, Gerald Kagan, 2010

机译：应用6Li扩散有序核磁共振光谱（DOsY）确定正丁基锂的溶液结构
8. Elemental Analysis of Biological Samples by Graphite Furnace, Inductively Coupled Plasma - Atomic Emission Spectroscopy (GF-ICP-AES) [R] . Winge, R. K., Fassel, V. A., Grabau, F., 1984

机译：石墨炉，电感耦合等离子体原子发射光谱法（GF-ICp-aEs）对生物样品的元素分析

Application of diffusion-ordered spectroscopy for the analysis of cancer related biological samples

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