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首页> 外文期刊>British journal of neurosurgery >Stereotactic intracavitary therapy of recurrent cystic craniopharyngioma by instillation of 90yttrium.
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Stereotactic intracavitary therapy of recurrent cystic craniopharyngioma by instillation of 90yttrium.

机译：滴注90钇的立体定向腔内治疗复发性囊性颅咽管瘤。

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Six consecutively presenting patients with craniopharyngiomas, (F:M = 4.2; mean age: 35.2 years, range 17-58) histologically proven by one or more previous operations, and with recurrence of a wholly or predominantly cystic nature, were treated by 90yttrium (90Y) radioisotope instillation into the cyst. Five patients had undergone external beam radiotherapy and the remaining patient had concomitant stereotactic radiosurgery to a co-existing solid component. Seven cysts in six patients have been treated. Five cysts, previously requiring repeated aspiration at intervals of 2-20 weeks have required no further surgical intervention following 90Y treatment (FU mean 3.5 years, range 1.2-7), although two of these required a second 90Y treatment. No patient developed a visual field defect or evidence of hypothalamic dysfunction. One patient died within a month of treatment from complications related to a solid recurrence. One patient developed a large solid/cystic recurrence at 4 months and died shortly thereafter from an unrelated cause. We summarize results from other series that have demonstrated the efficacy of this technique, usually as primary therapy, but this is the first series to demonstrate its usefulness as salvage therapy. The prospect of survival with good quality of life can be offered to patients with multiply recurrent disease who have exhausted all conventional means of treatment. In our experience intracavitary 90Y is a safe and highly effective means of controlling cystic recurrence in refractory craniopharyngioma. Some patients require more than one treatment.
机译：六个连续出现的颅咽管瘤患者（F：M = 4.2;平均年龄：35.2岁，范围17-58），经一项或多项既往手术在组织学上证实，并且复发为全囊性或以囊性为主，均接受90钇治疗（ 90Y）放射性同位素滴入囊肿。五名患者接受了外部束放射疗法，其余患者进行了立体定向放射外科手术，并同时存在一种固体成分。已经治疗了6名患者中的7个囊肿。 90 y治疗后，以前需要在2-20周的间隔内反复抽吸的5个囊肿不需要进行进一步的手术干预（FU平均3.5年，范围1.2-7），尽管其中两个需要第二次90Y治疗。没有患者出现视野缺损或下丘脑功能障碍的证据。一名患者在治疗后一个月内死于与坚实复发相关的并发症。一名患者在4个月时出现较大的实体/囊性复发，随后不久因不相关的原因死亡。我们总结了其他系列的结果，这些结果证明了该技术的有效性，通常作为主要疗法，但这是第一个证明其作为抢救疗法有用性的系列。可以为已经用尽所有常规治疗手段的多发性复发性疾病患者提供高质量的生存前景。根据我们的经验，腔内90Y是控制难治性颅咽管瘤囊性复发的一种安全有效的方法。一些患者需要不止一种治疗。

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