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首页> 外文期刊>British journal of neurosurgery >Management of granulomatous cerebral aspergillosis in immunocompetent adult patients: a review
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Management of granulomatous cerebral aspergillosis in immunocompetent adult patients: a review

机译：具有免疫功能的成年患者肉芽肿性脑曲霉病的处理：综述

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摘要

Cerebral aspergillosis, is an infrequent, opportunistic infection of the central nervous system that accounts for 5-10% of all intracranial fungal pathology. It is uncommon in immunocompetent patients and has a significant disease burden, with high morbidity and mortality, even with appropriate treatment. Basic principles of abscess management should be employed, including aspiration and targeted anti-fungal therapy for 12-18 months. However, reported outcomes with a purely minimally invasive approach are poor and there should be a low threshold for surgical excision, especially in resource poor settings and in patients with deteriorating neurology harbouring sizeable masses. Evidence favouring gross total excision over subtotal resection is lacking, however. It is notable that these recommendations are largely based on retrospective case series and isolated case reports. There is a need therefore for international collaboration to evaluate management strategies for immunocompetent patients with cerebral aspergillosis.
机译：脑曲霉病是中枢神经系统的偶发性机会性感染，占所有颅内真菌病理学的5-10％。它在具有免疫能力的患者中不常见，并且即使进行适当的治疗，也具有很大的疾病负担，较高的发病率和死亡率。应采用脓肿处理的基本原则，包括抽吸和针对性抗真菌治疗12-18个月。但是，报告的仅采用微创方法的结果较差，并且手术切除的门槛应较低，尤其是在资源贫乏地区以及神经病学恶化且肿块较大的患者中。然而，缺乏证据支持总切除比小手术切除要好。值得注意的是，这些建议主要基于回顾性案例系列和孤立的案例报告。因此，需要进行国际合作以评估具有免疫功能的脑曲霉病患者的治疗策略。

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