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首页> 外文期刊>International review of cytology >YidC as an essential and multifunctional component in membrane protein assembly.
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YidC as an essential and multifunctional component in membrane protein assembly.

机译：YidC是膜蛋白组装中必不可少的多功能组件。

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摘要

Membrane proteins fulfill a number of vital functions in prokaryotic and eukaryotic cells. They are often organized in multicomponent complexes, folded within the membrane bilayer and interacting with the cytoplasmic and periplasmic or external soluble compartments. For the biogenesis of integral membrane proteins, the essential biochemical steps are (1) the insertion and topogenesis of the transmembrane protein segments into the lipid bilayer, (2) the three-dimensional folding of the translocated hydrophilic domains, and (3) the assembly into multimeric complexes. Intensive research has elucidated the basic mechanisms of membrane protein insertion in the homologous translocation machineries of different cellular systems. Whereas the Sec translocation system is found in the endoplasmic reticulum of eukaryotic cells and in the prokaryotic plasma membrane, the YidC-Oxa1 membrane insertase is present in prokaryotic and organellar membranes. This review focuses on the discoveries of the YidC system in bacterial as well as the Oxa1/Alb3 protein family of eukaryotic cells and will particularly emphasize evolutionary aspects.
机译：膜蛋白在原核和真核细胞中具有许多重要功能。它们通常以多组分复合物的形式组织，折叠在膜双层中并与细胞质和周质或外部可溶性区室相互作用。对于完整膜蛋白的生物发生，基本的生化步骤是（1）跨膜蛋白片段插入脂质双层并在其中发生拓扑生成;（2）易位亲水域的三维折叠;以及（3）组装成多聚体复合物。深入的研究阐明了膜蛋白插入在不同细胞系统的同源易位机器中的基本机制。 Sec易位系统存在于真核细胞的内质网和原核质膜中，而YidC-Oxa1膜插入酶存在于原核和细胞器质膜中。这篇综述集中在细菌以及真核细胞的Oxa1 / Alb3蛋白家族中YidC系统的发现，并将特别强调进化方面。

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