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首页> 外文期刊>International review of cytology >Calcium dynamics: spatio-temporal organization from the subcellular to the organ level.
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Calcium dynamics: spatio-temporal organization from the subcellular to the organ level.

机译：钙动力学：从亚细胞到器官水平的时空组织。

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Many essential physiological processes are controlled by calcium. To ensure reliability and specificity, calcium signals are highly organized in time and space in the form of oscillations and waves. Interesting findings have been obtained at various scales, ranging from the stochastic opening of a single calcium channel to the intercellular calcium wave spreading through an entire organ. A detailed understanding of calcium dynamics thus requires a link between observations at different scales. It appears that some regulations such as calcium-induced calcium release or PLC activation by calcium, as well as the weak diffusibility of calcium ions play a role at all levels of organization in most cell types. To comprehend how calcium waves spread from one cell to another, specific gap-junctional coupling and paracrine signaling must also be taken into account. On the basis of a pluridisciplinar approach ranging from physics to physiology, a unified description of calcium dynamics is emerging, which could help understanding how such a small ion can mediate so many vital functions in living systems.
机译：钙控制着许多重要的生理过程。为了确保可靠性和特异性，钙信号以振荡和波动的形式在时间和空间上高度组织。从单个钙通道的随机开放到遍布整个器官的细胞间钙波，从不同规模获得了有趣的发现。因此，对钙动力学的详细了解需要在不同规模的观察之间建立联系。似乎某些法规，例如钙诱导的钙释放或钙对PLC的激活，以及钙离子的弱扩散性，在大多数细胞类型的所有组织水平中都起作用。为了理解钙波如何从一个细胞传播到另一个细胞，还必须考虑特定的间隙连接偶联和旁分泌信号传导。在从物理学到生理学的多学科方法的基础上，对钙动力学的统一描述正在出现，这可能有助于理解这种小离子如何介导生命系统中如此重要的功能。

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