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首页> 外文期刊>International medical journal: IMJ >Oxygen-Air Mixture Does Not Differ from Oxygen-Nitrous Oxide Mixture in Influencing PF Ratio in Healthy Patients Undergoing Laparoscopic Cholecystectomy
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Oxygen-Air Mixture Does Not Differ from Oxygen-Nitrous Oxide Mixture in Influencing PF Ratio in Healthy Patients Undergoing Laparoscopic Cholecystectomy

机译：在进行腹腔镜胆囊切除术的健康患者中，氧气-空气混合物与氧气-一氧化二氮混合物不会影响PF比

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Objective: This randomized single-blind study was designed to evaluate the effects of oxygen administration in air versus in N_2O to the PaO_2 / FiO_2 (PF ratio) in healthy patients undergoing laparoscopic cholecystectomy. Method: Sixteen patients with ASA I and II, age of less than 65 years and BMI of less than 40 were randomly recruited into two groups to receive either O_2 in air gas mixture (Group 1) or O_2 in N_2O gas mixture (Group 2). All patients received midazolam 7.5 mg po and 3 minutes preoxygenation with 100% O_2 prior to the induction of anaesthesia. Anaesthesia was induced with IV fentanyl 2 mcg/kg, propofol 2 mg/kg and paralyzed with IV rocuronium 0.6-0.8 mg/kg. All patients were maintained with FiO_2 of 0.35, sevoflurane with MAC of 1.0-1.2 and end CO_2 of 30-35 mmHg. Result: The peritoneal insufflations pressures were documented. A series of blood gases were taken prior to preoxygenation, at 30, 60 and 90 minutes post intubation. There was no overall difference between the two groups in terms of the PF ratio (p = 0.142), over time (p = 0.515) and time interaction within groups (p = 0.806) despite lower overall PF ratio in Group 2. Conclusion: There was no significant difference in the partial pressure of oxygen to the fractional inspired oxygen ratio (PF Ratio) in healthy patients ventilated with oxygen-Air or oxygen-nitrous oxide mixtures during laparoscopic cholecyctectomy.
机译：目的：这项随机单盲研究旨在评估健康人接受腹腔镜胆囊切除术时，空气中氧气供应与N_2O相比对PaO_2 / FiO_2（PF比）的影响。方法：将16例ASA I和II，年龄小于65岁且BMI小于40的患者随机分为两组，分别接受空气混合气中的O_2（第1组）或N_2O混合气中的O_2（第2组） 。所有患者在麻醉前接受咪达唑仑7.5 mg口服和100％O_2预氧化3分钟。静脉注射芬太尼2 mcg / kg，异丙酚2 mg / kg诱导麻醉，静脉注射罗库溴铵0.6-0.8 mg / kg麻醉。所有患者的FiO_2为0.35，七氟醚的MAC为1.0-1.2，终末CO_2为30-35 mmHg。结果：记录腹膜充气压力。在预充氧之前，在插管后30、60和90分钟采集一系列血液气体。尽管第2组的总PF率较低，但两组之间的PF比（p = 0.142），随时间的变化（p = 0.515）和组内的时间交互作用（p = 0.806）在总体上没有差异。在腹腔镜胆囊切除术中通入氧气-空气或氧气-一氧化二氮混合物的健康患者中，氧气的分压与吸入氧气分数（PF比）无显着差异。

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