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首页> 外文期刊>International review of psychiatry >Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: the role of PET and SPECT studies.
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Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: the role of PET and SPECT studies.

机译：双相情感障碍中的脑血流量，代谢，受体和转运蛋白变化：PET和SPECT研究的作用。

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摘要

The basic concepts of positron emission tomography (PET) and single photon emission computed tomography (SPECT) scanning are introduced, and the two modalities are compared. Applications to bipolar disorder (BD) are reviewed. Regional cerebral metabolic rate and blood flow, often used as surrogate measures of neuronal synaptic activity, are increased in the frontal lobes in both unipolar and bipolar depression. In mania, metabolism increases in the dorsal cingulate cortex, striatal regions, and the nucleus accumbens, as well as in limbic structures of the temporal lobes, but decreases in dorsolateral prefrontal cortex, possibly reflecting its loss of modulatory control over limbic structures. Specifically targeted PET radioligands are used to investigate neurotransmitter systems. D1 receptor binding potentials are reduced in frontal cortex, but striatal D2 receptor density is normal in all phases of non-psychotic BD. Psychotic BD patients show higher D2 receptor densities in the caudate, which correlate with the degree of psychosis but not mood symptoms. The serotonin transporter shows increased density in the thalamus, dorsal cingulate cortex, medial preftontal cortex, and insula of depressed BD patients. In the dorsal cingulate cortex and insula, it correlates with anxiety (and in the cingulate, with suicide attempts).
机译：介绍了正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）扫描的基本概念，并对两种方式进行了比较。审查对双相情感障碍（BD）的应用。在单相和双相抑郁症的额叶中，经常被用作神经元突触活动的替代指标的局部脑代谢率和血流量增加。在躁狂症中，新陈代谢在背扣带回皮质，纹状体区域和伏隔核以及颞叶的边缘结构中增加，但在背外侧前额叶皮质中减少，这可能反映了其对边缘结构的调节控制的丧失。专门针对性的PET放射性配体用于研究神经递质系统。 D1受体的结合电位在额叶皮层中降低，但是纹状体D2受体的密度在非精神病性BD的所有阶段都是正常的。精神病性BD患者的尾状D2受体密度更高，这与精神病的程度相关，但与情绪症状无关。血清素转运蛋白显示丘脑，背侧扣带回皮层，内侧前指前皮层以及抑郁的BD患者的岛突密度增加。在背侧扣带回皮层和岛中，它与焦虑相关（在背带扣带中与自杀企图相关）。

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