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首页> 外文期刊>International psychogeriatrics >The validity of amnestic MCI and non-amnestic MCI at age 75 in the prediction of Alzheimer's dementia and vascular dementia
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The validity of amnestic MCI and non-amnestic MCI at age 75 in the prediction of Alzheimer's dementia and vascular dementia

机译：75岁时遗忘性MCI和非遗忘性MCI在预测阿尔茨海默氏痴呆和血管性痴呆中的有效性

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Background: Clinical subtypes of mild cognitive impairment (MCI) were assigned as potential prodromes to various types of dementia. Amnestic MCI (aMCI) is said to have a high likelihood of progressing to Alzheimer's dementia (AD) and non-amnestic MCI (naMCI) subtypes are assumed to have a higher likelihood of progressing to non-AD dementia. The aim of this study was to investigate the prognostic accuracy of aMCI and naMCI for the development of AD, vascular dementia (VaD), and mixed dementia. Methods: In this longitudinal study, 487 subjects without dementia (cognitively healthy: n = 387; MCI cases: n = 115) aged 75 years at baseline, who participated in a population-based cohort study (Vienna Transdanube Aging study), were available for analysis. The observation period was 90 months. The diagnoses of the clinical MCI subtypes were made according to common criteria. The outcome (AD, VaD, mixed dementia) was described for both MCI subtypes. Diagnostic values of aMCI and naMCI according to incident AD, VaD, and mixed dementia were determined. Results: AD was the most common type of dementia following both MCI subtypes. Participants with aMCI were more likely to progress to AD than participants with naMCI. The proportion of incident VaD and mixed dementia did not differ concerning the MCI subtypes. The positive predictive value for both MCI subtypes was low (range: 1%-46%), whereas the negative predictive value was high (range: 86%-99%). Conclusions: The increased risk of clinical MCI subtypes for a particular type of dementia could only be confirmed for aMCI and incident AD.
机译：背景：轻度认知障碍（MCI）的临床亚型被指定为各种类型痴呆症的潜在症状。据说遗忘性MCI（aMCI）可能发展为阿尔茨海默氏痴呆（AD），非遗忘性MCI（naMCI）亚型被认为具有发展为非AD痴呆的可能性更高。这项研究的目的是调查aMCI和naMCI对AD，血管性痴呆（VaD）和混合性痴呆的发展的预后准确性。方法：在这项纵向研究中，有487位基线时年龄为75岁的无痴呆患者（认知健康：n = 387; MCI病例：n = 115），他们参加了一项基于人群的队列研究（Vienna Transdanube Aging研究）。进行分析。观察期为90个月。根据常规标准对临床MCI亚型进行诊断。描述了两种MCI亚型的结局（AD，VaD，混合性痴呆）。根据事件AD，VaD和混合性痴呆确定aMCI和naMCI的诊断值。结果：AD是继两种MCI亚型之后最常见的痴呆类型。与naMCI参与者相比，aMCI参与者更容易发展为AD。在MCI亚型方面，VaD事件和混合性痴呆的比例没有差异。两种MCI亚型的阳性预测值均较低（范围：1％-46％），而阴性预测值较高（范围：86％-99％）。结论：特定类型的痴呆的临床MCI亚型风险增加只能通过aMCI和AD事件得以证实。

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