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首页> 外文期刊>British journal of neurosurgery >Factors affecting diagnostic yield in needle biopsy for brain lesions
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Factors affecting diagnostic yield in needle biopsy for brain lesions

机译：影响脑部病变的穿刺活检诊断率的因素

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Introduction. We analyse the factors that are associated with the diagnostic yield of needle brain biopsy. Material and methods. We present a retrospective series of 124 consecutive biopsies in a 30-month period. Patients' demographics (age, gender), lesion topography (side, location, depth), lesion characteristics (histology, volume, radiological enhancement), type of biopsy procedure (freehand, ultrasound guided, frameless and frame-based stereotactic) and the use of intraoperative histologic examination were correlated with the diagnostic rate. Descriptive statistics and a nominal logistic regression model were used to evaluate the factors influencing diagnostic yield. Results. 63 men and 61 women were included in the study with mean age 59.2 (range: 16-86). 55 were frame-based stereotactic biopsies, 33 were frameless stereotactic biopsies, 29 biopsies were performed under ultrasound guidance and 7 freehand. The diagnostic yield in our series is 93.5%. The gender, lesion topography, biopsy method, use of intraoperative histology and enhancement did not correlate with the diagnostic yield. Younger age had a negative impact on diagnostic yield. 6 out of 8 inconclusive biopsies were in non-glial lesions (p < 0.05). The odds of obtaining a positive diagnosis increased sevenfold with every cc increase in lesion volume. Conclusion. The age of the patient, the volume and the histology of the brain lesion had an impact on the diagnostic yield of needle biopsy. None of the other factors significantly influenced the diagnostic rate.
机译：介绍。我们分析了与针头脑活检诊断率相关的因素。材料与方法。我们提出了一个回顾性系列，在30个月内进行了124次连续活检。患者的人口统计资料（年龄，性别），病变地形（侧面，位置，深度），病变特征（组织学，体积，放射学增强），活检程序类型（徒手，超声引导，无框架和基于框架的立体定向）及其用途术中组织学检查的时间与诊断率相关。描述性统计和名义Logistic回归模型用于评估影响诊断率的因素。结果。该研究包括63名男性和61名女性，平均年龄59.2（范围：16-86）。 55例是基于框架的立体定向活检，33例是无框架立体定向活检，29例活检在超声引导下进行，7例徒手进行。我们系列的诊断产率为93.5％。性别，病变部位，活检方法，术中组织学检查的使用和增强与诊断率无关。年龄过小对诊断率产生负面影响。 8例不确定的活检中有6例为非神经胶质病变（p <0.05）。病灶体积每增加cc，获得阳性诊断的几率就会增加七倍。结论。患者的年龄，脑部病变的数量和组织学对穿刺活检的诊断率有影响。其他因素均未显着影响诊断率。

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