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首页> 外文期刊>British journal of neurosurgery >Diffusion tensor invasive phenotypes can predict progression-free survival in glioblastomas
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Diffusion tensor invasive phenotypes can predict progression-free survival in glioblastomas

机译：扩散张量侵入表型可以预测胶质母细胞瘤的无进展生存期

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Introduction. Glioblastomas multiformes (GBM) remain incurable in most cases. Their invasion into normal brain makes current therapies ineffective. Post-mortem studies suggest about a 25% of GBMs invade less than 1 cm from the tumour bulk and 20% invade more than 3 cm. Aim of study. The study aims to use DTI to assess tumour extension and determine how previously reported patterns relate to the progression-free survival (PFS). Materials and methods. Twenty-five patients with GBM treated according to the EORTC/NCIC protocol were retrospectively analysed. Patients were imaged post-operatively at 1.5 T. The sequences were composed of standard anatomical and a standard DTI sequence. As described earlier p and q maps were constructed. For each of the p and q maps, regions of interest were drawn around the visible abnormality. Patients were assigned a diffuse, localised or minimally invasive pattern. Progression was defined according to the RANO criteria and PFS determined in days. Kaplan-Meier plots of survival for the three groups were plotted as were the proportion of patients who had not progressed at 24 months. Results. The median PFS for the diffuse group was 278 days, for the localised group 605 days and 820 days for the minimally invasive group. Three-fourth of the minimally invasive group were progression-free at 24 months (LOG RANK 9.25; p = 0.010). Conclusion. It is possible to identify three invasive phenotypes in GBMs using Diffusion tensor imaging , and these three phenotypes have different progression free survival. A minimal phenotype (20% of patients) predicts a greater delay to progression.
机译：介绍。在大多数情况下，多形胶质母细胞瘤（GBM）仍无法治愈。它们侵入正常大脑使目前的治疗无效。验尸研究表明，大约25％的GBM侵入距离肿瘤块不到1厘米的地方，而20％的GBM侵入到超过3厘米的地方。学习目的。该研究旨在利用DTI评估肿瘤的扩展并确定先前报道的模式与无进展生存期（PFS）的关系。材料和方法。回顾性分析了根据EORTC / NCIC方案治疗的25例GBM患者。术后1.5 T对患者成像。序列由标准解剖结构和标准DTI序列组成。如前所述，构建了p和q图。对于每个p和q映射，在可见异常周围绘制了感兴趣的区域。为患者分配了弥散性，局限性或微创模式。根据RANO标准定义进展，以天为单位确定PFS。绘制了三组的Kaplan-Meier生存图以及24个月未进展的患者比例。结果。弥漫性组的中位PFS为278天，局部组为605天，微创组为820天。微创组中有四分之三在24个月时无进展（LOG RANK 9.25; p = 0.010）。结论。使用扩散张量成像可以鉴定GBM中的三种侵入性表型，并且这三种表型具有不同的无进展生存期。最小的表型（占患者的20％）预示了病程的更大延迟。

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