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首页> 外文期刊>Investigative ophthalmology & visual science >Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.
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Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.

机译：SD-OCT上分割的玻璃膜疣与彩色眼底照片上描绘的玻璃膜疣的定量比较。

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PURPOSE: Spectral domain-optical coherence tomography (SD-OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were compared to those identified from review of digital color fundus photographs (CFPs). METHODS: Twelve eyes with nonneovascular AMD were prospectively imaged with digital CFP and SD-OCT. For each eye, areas on CFP in which at least two of three retina specialists agreed on drusen presence produced the composite CFP drusen map. Automated image analysis produced another CFP map. Areas identified as drusen by segmentation on SD-OCT B-scans were plotted as the SD-OCT drusen map. The CFP and SD-OCT maps were compared and agreement was quantified. Disagreement was characterized into distinct types, and the frequency of each type was quantified. RESULTS: There was general agreement between CFP and SD-OCT in identifying presence and absence of drusen, with mean agreement in 82% +/- 9% of total image pixels. Most disagreement (80% +/- 15%) occurred at drusen margins. There was a trend toward greater detection of drusen with SD-OCT in eyes with larger drusen and with hyperpigmentation. There was a trend toward greater detection of smaller drusen by CFP. CONCLUSIONS: Good agreement was demonstrated in drusen detection between CFP and SD-OCT. Areas of disagreement underscore limitations of CFP-based measurement of drusen, particularly in the sizing of large, soft drusen. SD-OCT shows great promise as an adjunctive tool for assessing drusen burden in AMD. (ClinicalTrials.gov number, NCT00734487.).
机译：目的：光谱域光学相干断层扫描（SD-OCT）可能对有效测量年龄相关性黄斑变性（AMD）患者的玻璃膜疣。将通过在SD-OCT上对玻璃疣进行半自动分割而确定为玻璃疣的区域与通过检查数字彩色眼底照片（CFP）确定的区域进行了比较。方法：用数字CFP和SD-OCT对十二眼非血管性AMD进行了前瞻性成像。对于每只眼睛，在CFP上至少三分之二的视网膜专家就玻璃膜疣存在达成共识的区域制作了CFP玻璃膜疣综合图。自动化图像分析产生了另一张CFP图。通过在SD-OCT B扫描上进行分割确定为玻璃疣的区域被绘制为SD-OCT玻璃疣图。比较了CFP和SD-OCT图，并量化了一致性。分歧被分为不同的类型，每种类型的发生频率也被量化。结果：CFP和SD-OCT在确定是否存在玻璃疣时达成了普遍共识，在总图像像素中有82％+/- 9％的平均一致性。大多数分歧（80％+/- 15％）发生在玻璃疣边缘。在具有较大色素沉着和色素沉着的眼中，存在使用SD-OCT更好地检测玻璃疣的趋势。有一种趋势是CFP会更多地发现较小的玻璃疣。结论：CFP和SD-OCT之间在玻璃膜疣检测中显示出良好的一致性。分歧的领域强调了基于CFP的玻璃疣的测量的局限性，特别是在大型，柔软的玻璃疣的尺寸确定方面。 SD-OCT作为评估AMD玻璃疣负荷的辅助工具具有广阔的前景。 （ClinicalTrials.gov编号，NCT00734487。）。

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