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首页> 外文期刊>Investigative ophthalmology & visual science >Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.
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Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats.

机译：在皇家外科医学院的大鼠中，经角膜电刺激可促进光感受器的存活并保持视网膜功能。

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PURPOSE: To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on photoreceptors and preserves retinal function in Royal College of Surgeons (RCS) rats. METHODS: Three-week-old RCS rats received TES through a contact lens electrode on the left eye weekly for 2 to 6 weeks. The right eyes received sham stimulation on the same days. Electroretinograms (ERGs) were recorded from the rats at 3 weeks (before TES), and at 5, 7, and 9 weeks of age. After the ERG recordings, the rats were killed for morphologic analyses of the retina. RESULTS: Morphologic analyses showed that the mean thickness of the outer nuclear layer (ONL) at each time point was significantly thicker in eyes treated with TES of 100 muA than in eyes with sham stimulation (TES 100 muA versus sham: 5, 7, and 9 weeks of age; P < 0.001). ERG studies showed that TES also significantly preserved retinal function up to 7 weeks of age, but did not preserve retinal function at 9 weeks of age. CONCLUSIONS: TES prolongs the survival of photoreceptors and delays the decrease of retinal function in RCS rats. Although further investigations are necessary before using TES on patients, these findings indicate that TES may be a therapeutic treatment for some patients with diseases of the photoreceptors such as retinitis pigmentosa.
机译：目的：确定在皇家外科医学院（RCS）的大鼠中，经角膜电刺激（TES）是否对光感受器具有神经保护作用并保留视网膜功能。方法：三周大的RCS大鼠每周通过左眼的隐形眼镜电极接受TES，持续2至6周。右眼在同一天受到假刺激。在第3周（TES之前）以及第5、7和9周龄时从大鼠记录视网膜电图（ERG）。在ERG记录之后，将大鼠处死以进行视网膜的形态学分析。结果：形态学分析表明，用100μATES进行处理的眼睛在每个时间点的外核层（ONL）的平均厚度均比用假刺激刺激的眼睛要厚（TES 100μA对假性：5、7和9周龄; P <0.001）。 ERG研究表明，TES直到7周龄时仍能显着保留视网膜功能，但在9周龄时仍未保留视网膜功能。结论：TES延长了RCS大鼠的感光细胞的存活，并延缓了视网膜功能的下降。尽管在对患者使用TES之前需要进行进一步的研究，但这些发现表明TES可能是一些患有感光细胞疾病（例如色素性视网膜炎）的患者的治疗方法。

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