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首页> 外文期刊>Investigative ophthalmology & visual science >Vertical optokinetic nystagmus and saccades in normal human subjects.
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Vertical optokinetic nystagmus and saccades in normal human subjects.

机译:正常人类受试者的垂直视动眼球震颤和眼球扫视。

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PURPOSE: Optokinetic stimulation induces nystagmus that can be used to test the saccadic and visual-tracking systems in some patients with voluntary gaze palsies. The purpose of this study was to characterize vertical optokinetic nystagmus (OKN) in normal human subjects, comparing the dynamic properties of the quick phases with voluntary saccades of similar size and measuring the slow-phase responses to visual stimuli with a range of spatial and temporal frequencies. METHODS: Vertical OKN and saccades were recorded in 10 healthy adult subjects (age range, 24-54 years) using the magnetic search coil technique. The optokinetic (OK) stimulus subtended 72 degrees horizontally and 60 degrees vertically, consisted of black-and-white stripes with a spatial frequency of 0.04, 0.08, or 0.16 cyc/deg, and moved vertically at 10 to 50 deg/s. Vertical and horizontal saccades to visual targets separated by 1 degrees to 10 degrees were also elicited. RESULTS: Over 95% of quick phases were less than 10 degrees in amplitude; voluntary saccades of this amplitude range were slightly faster than quick phases of similar size. The amplitude-peak velocity relationships and amplitude-duration relationships of upward and downward fast movements (saccades or quick phases) were similar. Most vertical slow-phase OK responses showed greater gain for upward stimulus motion. OK gain decreased with increasing stimulus speed and increased spatial frequency, so that there was a general decrease in slow-phase velocity gain with increasing temporal frequency. CONCLUSIONS: In this study, the best OK responses were obtained using stripes with lower spatial frequencies and lower stripe speeds (0.4 cyc/deg at 10 deg/s). The dynamic properties of vertical quick phases of nystagmus are similar enough to those of voluntary saccades for OK stimulation to be used as a clinical test of the vertical saccadic system in individuals with voluntary gaze palsy.
机译:目的:光动力刺激会引起眼球震颤,可用于检测某些自愿性视力麻痹患者的眼跳和视觉跟踪系统。这项研究的目的是表征正常人类受试者的垂直视动眼球震颤(OKN),比较快相与类似大小的自愿扫视的动态特性,并测量在一定时空范围内对视觉刺激的慢相反应频率。方法:使用磁搜索线圈技术在10名健康成人受试者(年龄范围24-54岁)中记录垂直OKN和扫视运动。光动力(OK)刺激在水平方向上对向72度,在垂直方向上对向60度,由黑白条纹组成,空间频率为0.04、0.08或0.16 cyc / deg,并以10至50 deg / s垂直移动。还引发了将视觉目标垂直和水平扫视(相隔1度到10度)的情况。结果:超过95%的快速相位振幅小于10度;这个幅度范围的自愿扫视比相似大小的快速相位略快。上下快速运动(扫视或快速相位)的振幅峰速度关系和振幅持续时间关系相似。大多数垂直慢相OK响应显示出向上刺激运动的更大增益。 OK增益随刺激速度的增加和空间频率的增加而降低,因此慢相速度增益随时间频率的增加而普遍下降。结论:在这项研究中,使用具有较低空间频率和较低条纹速度(在10 deg / s下为0.4 cyc / deg)的条纹可获得最佳的OK响应。眼球震颤的垂直快速相的动态特性与用于OK刺激的自愿扫视的动态特性足够相似,可以用作具有自愿凝视性麻痹的个体的垂直扫视系统的临床测试。

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