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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?
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Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?

机译：精神分裂症的必然放电功能障碍：可以解释听觉幻觉吗？

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摘要

Failure of corollary discharge, a mechanism for distinguishing self-generated from externally generated percepts, has been posited to underlie certain positive symptoms of schizophrenia, including auditory hallucinations. Although originally described in the visual system, corollary discharge may exist in the auditory system, whereby signals from motor speech commands prepare auditory cortex for self-generated speech. While associated with sensorimotor systems, it might also apply to inner speech or thought, regarded as our most complex motor act. In this paper, we describe the results of a series of studies in which we have shown that: (1) event-related brain potentials (ERPs) can be used to demonstrate the corollary discharge phenomenon during talking, (2) corollary discharge is abnormal in patients with schizophrenia, (3) EEG gamma band coherence between frontal and temporal lobes is greater during talking than listening and is disrupted by distorted feedback during talking in normals, and (4) patients with schizophrenia do not show this pattern for EEG gamma coherence. While these studies have identified ERPs and EEG gamma coherence indices of the efference copy/corollary discharge system and documented abnormalities in these systems in patients with schizophrenia, we have so far had limited success in establishing a relationship between these neurobiologic indicators of corollary discharge abnormality and reports of hallucinations in patients.
机译：推论失败的推论是将自我产生的与外部产生的感知区别开来的机制，它被认为是精神分裂症某些积极症状的基础，包括听觉幻觉。虽然最初是在视觉系统中描述的，但是共鸣放电可能存在于听觉系统中，因此来自运动语音命令的信号会为自生语音准备听觉皮层。虽然与感觉运动系统相关联，但它也可能适用于被认为是我们最复杂的运动行为的内在言语或思想。在本文中，我们描述了一系列研究的结果，这些研究表明：（1）事件相关的脑电势（ERP）可用于证明谈话过程中的必然放电现象，（2）必然放电异常在精神分裂症患者中，（3）谈话期间额叶和颞叶之间的EEG伽马带相干性大于听觉，并且在正常情况下会因谈话中的反馈失真而中断，并且（4）精神分裂症患者未显示出这种EEG伽马相干性模式。尽管这些研究已经确定了精神分裂症患者依从性复制/推定放电系统的ERPs和EEGγ相干指数，并记录了这些系统中的异常，但迄今为止，我们在建立推论异常/推论异常的这些神经生物学指标与神经系统生物学指标之间的关系方面取得了有限的成功。患者出现幻觉的报道。

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