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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Evidence for unaltered brain electrical topography during prefrontal response control in cycloid psychoses.
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Evidence for unaltered brain electrical topography during prefrontal response control in cycloid psychoses.

机译：摆线性精神病患者前额叶反应控制期间未改变的脑电地形的证据。

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OBJECTIVE: Prefrontal structures such as the anterior cingulate cortex (ACC) play a decisive role in processes of action monitoring and response control, functions often impaired in schizophrenia. Patients with cycloid psychoses exhibit some characteristic neurophysiological features not indicative of the cerebral hypofrontality observed in schizophrenia. This study aimed at examining if cycloid psychoses-unlike schizophrenias-involve a normal brain-electrical topography during a task demanding prefrontal response control. METHODS: Thirty-seven patients with cycloid psychoses and 37 healthy controls were investigated electrophysiologically while performing a Continuous Performance Test (CPT). Topographical analyses were conducted to individually quantify the Nogo-anteriorisation (NGA) as a neurophysiological index of prefrontal response control. RESULTS: The patients exhibited an unaltered topography with a mean NGA not significantly different from the controls. They did, however, differ from the control group regarding their Global Field Power (GFP), with a significantly reduced GFP (p<0.001) and decreased latencies (p<0.01) during Nogo trials. On a behavioral level, patients exhibited prolonged reaction times and an increased rate of omission errors. CONCLUSIONS: The investigated patients showed an activation of specific (presumably frontal) brain areas during Nogo trials, resulting in a frontalisation of the brain-electrical field comparable to the control group. However, the strength of this activation was apparently reduced. The patients' unaltered topographical pattern contrasts with previous findings in schizophrenic patients and supports the hypothesis that cycloid psychoses entail less severe prefrontal deficits than schizophrenias, which might be an indication of different biological backgrounds for both groups of endogenous psychoses.
机译：目的：前额叶结构，例如前扣带回皮层（ACC）在动作监测和反应控制过程中起决定性作用，在精神分裂症中经常受损。患有摆线性精神病的患者表现出某些特征性的神经生理学特征，并不表示在精神分裂症中观察到的脑功能低下。这项研究旨在检查与精神分裂症不同的摆线性精神病是否在需要前额叶反应控制的任务期间涉及正常的脑电地形。方法：在进行连续性能测试（CPT）的同时，对37例摆线性肌病患者和37名健康对照者进行了电生理检查。进行地形分析以单独量化Nogo-前验化（NGA）作为前额叶反应控制的神经生理指标。结果：患者的地形保持不变，平均NGA与对照组无明显差异。然而，他们在全球田间力量（GFP）方面与对照组确实有所不同，在Nogo试验期间，GFP显着降低（p <0.001），潜伏期缩短（p <0.01）。在行为水平上，患者表现出延长的反应时间和增加的遗漏错误率。结论：被调查的患者在Nogo试验期间显示出特定的（可能是额叶）大脑区域的激活，导致与对照组相当的大脑电场的额叶化。但是，这种活化的强度明显降低了。患者的不变地形特征与精神分裂症患者的先前发现形成对比，并支持以下假设：摆线性精神病比精神分裂症所引起的前额叶赤字不那么严重，这可能表明两组内源性精神病的生物学背景不同。

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